% IMPORTANT: The following is UTF-8 encoded. This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.
@ARTICLE{Litmeier:163481,
author = {Litmeier, Simon and Meinel, Thomas R and von Rennenberg,
Regina and Kniepert, Joachim U and Audebert, Heinrich J and
Endres, Matthias and Jung, Simon and Scheitz, Jan F. and
Nolte, Christian},
title = {{C}oronary angiography in acute ischemic stroke patients:
frequency and determinants of pathological findings in a
multicenter cohort study.},
journal = {Journal of neurology},
volume = {269},
number = {7},
issn = {0340-5354},
address = {Berlin},
publisher = {Springer},
reportid = {DZNE-2022-00241},
pages = {3745-3751},
year = {2022},
note = {ISSN 1432-1459 not unique: **2 hits**.(CC BY)},
abstract = {Myocardial injury as indicated by cardiac troponin
elevation is associated with poor prognosis in acute stroke
patients. Coronary angiography (CAG) is the diagnostic
gold-standard to rule-out underlying obstructive coronary
artery disease (CAD) in these patients. However, weighing
risks and benefits of coronary angiography (CAG) against
each other is particularly challenging, because stroke
patients undergoing CAG may have a higher risk for secondary
intracranial bleeding. Current guidelines remain vague.
Thus, the aim of this study was to analyze frequency of
pathological findings of CAG and associated clinical
factors.We analyzed indications and frequency of CAG
performed in acute ischemic stroke patients in clinical
routine in two European tertiary care hospitals from 2011 to
2018. All data were obtained retrospectively. Multiple
logistic regression analyses were performed to identify
variables associated with absence of obstructive coronary
artery disease defined as presence of at least one coronary
vessel stenosis ≥ $50\%.A$ total of 139 AIS patients
underwent CAG. Frequent indications for CAG were suspected
acute coronary syndrome (N = 114) or scheduled cardiac
surgery (N = 25). Acute coronary stenting was applied in
51/139 patients. Among patients with suspected acute
coronary syndrome, no obstructive CAD was found in 27/114
patients. Absence of obstructive CAD was associated with
insular cortex lesions, no clinical symptoms for ACS, less
than three cardiovascular risk factors, younger age and
normal wall motion.Several variables suggest absence of CAD
in AIS patients and may help in clinical decision making in
stroke patients with myocardial injury.},
keywords = {Acute Coronary Syndrome: complications / Acute Coronary
Syndrome: diagnosis / Coronary Angiography / Coronary Artery
Disease: complications / Coronary Artery Disease: diagnosis
/ Humans / Ischemic Stroke / Retrospective Studies / Risk
Factors / Stroke: complications / Stroke: diagnostic imaging
/ Stroke: epidemiology / Acute ischemic stroke (Other) /
Heart and brain axis (Other) / Myocardial injury (Other) /
Stroke-heart-syndrome (Other)},
cin = {AG Endres},
ddc = {610},
cid = {I:(DE-2719)1811005},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC9217821},
pubmed = {pmid:35182178},
doi = {10.1007/s00415-022-11001-5},
url = {https://pub.dzne.de/record/163481},
}