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@ARTICLE{Litmeier:163481,
      author       = {Litmeier, Simon and Meinel, Thomas R and von Rennenberg,
                      Regina and Kniepert, Joachim U and Audebert, Heinrich J and
                      Endres, Matthias and Jung, Simon and Scheitz, Jan F. and
                      Nolte, Christian},
      title        = {{C}oronary angiography in acute ischemic stroke patients:
                      frequency and determinants of pathological findings in a
                      multicenter cohort study.},
      journal      = {Journal of neurology},
      volume       = {269},
      number       = {7},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DZNE-2022-00241},
      pages        = {3745-3751},
      year         = {2022},
      note         = {ISSN 1432-1459 not unique: **2 hits**.(CC BY)},
      abstract     = {Myocardial injury as indicated by cardiac troponin
                      elevation is associated with poor prognosis in acute stroke
                      patients. Coronary angiography (CAG) is the diagnostic
                      gold-standard to rule-out underlying obstructive coronary
                      artery disease (CAD) in these patients. However, weighing
                      risks and benefits of coronary angiography (CAG) against
                      each other is particularly challenging, because stroke
                      patients undergoing CAG may have a higher risk for secondary
                      intracranial bleeding. Current guidelines remain vague.
                      Thus, the aim of this study was to analyze frequency of
                      pathological findings of CAG and associated clinical
                      factors.We analyzed indications and frequency of CAG
                      performed in acute ischemic stroke patients in clinical
                      routine in two European tertiary care hospitals from 2011 to
                      2018. All data were obtained retrospectively. Multiple
                      logistic regression analyses were performed to identify
                      variables associated with absence of obstructive coronary
                      artery disease defined as presence of at least one coronary
                      vessel stenosis ≥ $50\%.A$ total of 139 AIS patients
                      underwent CAG. Frequent indications for CAG were suspected
                      acute coronary syndrome (N = 114) or scheduled cardiac
                      surgery (N = 25). Acute coronary stenting was applied in
                      51/139 patients. Among patients with suspected acute
                      coronary syndrome, no obstructive CAD was found in 27/114
                      patients. Absence of obstructive CAD was associated with
                      insular cortex lesions, no clinical symptoms for ACS, less
                      than three cardiovascular risk factors, younger age and
                      normal wall motion.Several variables suggest absence of CAD
                      in AIS patients and may help in clinical decision making in
                      stroke patients with myocardial injury.},
      keywords     = {Acute Coronary Syndrome: complications / Acute Coronary
                      Syndrome: diagnosis / Coronary Angiography / Coronary Artery
                      Disease: complications / Coronary Artery Disease: diagnosis
                      / Humans / Ischemic Stroke / Retrospective Studies / Risk
                      Factors / Stroke: complications / Stroke: diagnostic imaging
                      / Stroke: epidemiology / Acute ischemic stroke (Other) /
                      Heart and brain axis (Other) / Myocardial injury (Other) /
                      Stroke-heart-syndrome (Other)},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9217821},
      pubmed       = {pmid:35182178},
      doi          = {10.1007/s00415-022-11001-5},
      url          = {https://pub.dzne.de/record/163481},
}