Home > Publications Database > Coronary angiography in acute ischemic stroke patients: frequency and determinants of pathological findings in a multicenter cohort study. > print

001     163481
005     20240320115519.0
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024 7 _ |a 0340-5354
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037 _ _ |a DZNE-2022-00241
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Litmeier, Simon
|0 P:(DE-2719)9001453
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245 _ _ |a Coronary angiography in acute ischemic stroke patients: frequency and determinants of pathological findings in a multicenter cohort study.
260 _ _ |a Berlin
|c 2022
|b Springer
336 7 _ |a article
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520 _ _ |a Myocardial injury as indicated by cardiac troponin elevation is associated with poor prognosis in acute stroke patients. Coronary angiography (CAG) is the diagnostic gold-standard to rule-out underlying obstructive coronary artery disease (CAD) in these patients. However, weighing risks and benefits of coronary angiography (CAG) against each other is particularly challenging, because stroke patients undergoing CAG may have a higher risk for secondary intracranial bleeding. Current guidelines remain vague. Thus, the aim of this study was to analyze frequency of pathological findings of CAG and associated clinical factors.We analyzed indications and frequency of CAG performed in acute ischemic stroke patients in clinical routine in two European tertiary care hospitals from 2011 to 2018. All data were obtained retrospectively. Multiple logistic regression analyses were performed to identify variables associated with absence of obstructive coronary artery disease defined as presence of at least one coronary vessel stenosis ≥ 50%.A total of 139 AIS patients underwent CAG. Frequent indications for CAG were suspected acute coronary syndrome (N = 114) or scheduled cardiac surgery (N = 25). Acute coronary stenting was applied in 51/139 patients. Among patients with suspected acute coronary syndrome, no obstructive CAD was found in 27/114 patients. Absence of obstructive CAD was associated with insular cortex lesions, no clinical symptoms for ACS, less than three cardiovascular risk factors, younger age and normal wall motion.Several variables suggest absence of CAD in AIS patients and may help in clinical decision making in stroke patients with myocardial injury.
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542 _ _ |i 2022-02-19
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|u https://creativecommons.org/licenses/by/4.0
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650 _ 7 |a Acute ischemic stroke
|2 Other
650 _ 7 |a Heart and brain axis
|2 Other
650 _ 7 |a Myocardial injury
|2 Other
650 _ 7 |a Stroke-heart-syndrome
|2 Other
650 _ 2 |a Acute Coronary Syndrome: complications
|2 MeSH
650 _ 2 |a Acute Coronary Syndrome: diagnosis
|2 MeSH
650 _ 2 |a Coronary Angiography
|2 MeSH
650 _ 2 |a Coronary Artery Disease: complications
|2 MeSH
650 _ 2 |a Coronary Artery Disease: diagnosis
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Ischemic Stroke
|2 MeSH
650 _ 2 |a Retrospective Studies
|2 MeSH
650 _ 2 |a Risk Factors
|2 MeSH
650 _ 2 |a Stroke: complications
|2 MeSH
650 _ 2 |a Stroke: diagnostic imaging
|2 MeSH
650 _ 2 |a Stroke: epidemiology
|2 MeSH
700 1 _ |a Meinel, Thomas R
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700 1 _ |a von Rennenberg, Regina
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700 1 _ |a Endres, Matthias
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700 1 _ |a Jung, Simon
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700 1 _ |a Scheitz, Jan F.
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700 1 _ |a Nolte, Christian
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