TY  - JOUR
AU  - Andree, Andrea
AU  - Li, Ningfei
AU  - Butenko, Konstantin
AU  - Kober, Maria
AU  - Chen, Jia Zhi
AU  - Higuchi, Takahiro
AU  - Fauser, Mareike
AU  - Storch, Alexander
AU  - Ip, Chi Wang
AU  - Kühn, Andrea
AU  - Horn, Andreas
AU  - van Rienen, Ursula
TI  - Deep brain stimulation electrode modeling in rats.
JO  - Experimental neurology
VL  - 350
SN  - 0014-4886
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2022-00254
SP  - 113978
PY  - 2022
N1  - (CC BY-NC-ND)
AB  - Deep Brain Stimulation (DBS) is an efficacious treatment option for an increasing range of brain disorders. To enhance our knowledge about the mechanisms of action of DBS and to probe novel targets, basic research in animal models with DBS is an essential research base. Beyond nonhuman primate, pig, and mouse models, the rat is a widely used animal model for probing DBS effects in basic research. Reconstructing DBS electrode placement after surgery is crucial to associate observed effects with modulating a specific target structure. Post-mortem histology is a commonly used method for reconstructing the electrode location. In humans, however, neuroimaging-based electrode localizations have become established. For this reason, we adapt the open-source software pipeline Lead-DBS for DBS electrode localizations from humans to the rat model. We validate our localization results by inter-rater concordance and a comparison with the conventional histological method. Finally, using the open-source software pipeline OSS-DBS, we demonstrate the subject-specific simulation of the VTA and the activation of axon models aligned to pathways representing neuronal fibers, also known as the pathway activation model. Both activation models yield a characterization of the impact of DBS on the target area. Our results suggest that the proposed neuroimaging-based method can precisely localize DBS electrode placements that are essentially rater-independent and yield results comparable to the histological gold standard. The advantages of neuroimaging-based electrode localizations are the possibility of acquiring them in vivo and combining electrode reconstructions with advanced imaging metrics, such as those obtained from diffusion or functional magnetic resonance imaging (MRI). This paper introduces a freely available open-source pipeline for DBS electrode reconstructions in rats. The presented initial validation results are promising.
KW  - Animals
KW  - Axons
KW  - Deep Brain Stimulation
KW  - Electrodes, Implanted
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Models, Animal
KW  - Models, Neurological
KW  - Neuroimaging
KW  - Rats
KW  - Reproducibility of Results
KW  - Software
KW  - Ventral Tegmental Area: diagnostic imaging
KW  - Animal models (Other)
KW  - Deep brain stimulation (Other)
KW  - Neuroimaging (Other)
KW  - Open-source (Other)
KW  - Parkinson's disease (Other)
KW  - Rat (Other)
KW  - Research software (Other)
KW  - Rodent (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35026227
DO  - DOI:10.1016/j.expneurol.2022.113978
UR  - https://pub.dzne.de/record/163494
ER  -