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@ARTICLE{Andree:163494,
      author       = {Andree, Andrea and Li, Ningfei and Butenko, Konstantin and
                      Kober, Maria and Chen, Jia Zhi and Higuchi, Takahiro and
                      Fauser, Mareike and Storch, Alexander and Ip, Chi Wang and
                      Kühn, Andrea and Horn, Andreas and van Rienen, Ursula},
      title        = {{D}eep brain stimulation electrode modeling in rats.},
      journal      = {Experimental neurology},
      volume       = {350},
      issn         = {0014-4886},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2022-00254},
      pages        = {113978},
      year         = {2022},
      note         = {(CC BY-NC-ND)},
      abstract     = {Deep Brain Stimulation (DBS) is an efficacious treatment
                      option for an increasing range of brain disorders. To
                      enhance our knowledge about the mechanisms of action of DBS
                      and to probe novel targets, basic research in animal models
                      with DBS is an essential research base. Beyond nonhuman
                      primate, pig, and mouse models, the rat is a widely used
                      animal model for probing DBS effects in basic research.
                      Reconstructing DBS electrode placement after surgery is
                      crucial to associate observed effects with modulating a
                      specific target structure. Post-mortem histology is a
                      commonly used method for reconstructing the electrode
                      location. In humans, however, neuroimaging-based electrode
                      localizations have become established. For this reason, we
                      adapt the open-source software pipeline Lead-DBS for DBS
                      electrode localizations from humans to the rat model. We
                      validate our localization results by inter-rater concordance
                      and a comparison with the conventional histological method.
                      Finally, using the open-source software pipeline OSS-DBS, we
                      demonstrate the subject-specific simulation of the VTA and
                      the activation of axon models aligned to pathways
                      representing neuronal fibers, also known as the pathway
                      activation model. Both activation models yield a
                      characterization of the impact of DBS on the target area.
                      Our results suggest that the proposed neuroimaging-based
                      method can precisely localize DBS electrode placements that
                      are essentially rater-independent and yield results
                      comparable to the histological gold standard. The advantages
                      of neuroimaging-based electrode localizations are the
                      possibility of acquiring them in vivo and combining
                      electrode reconstructions with advanced imaging metrics,
                      such as those obtained from diffusion or functional magnetic
                      resonance imaging (MRI). This paper introduces a freely
                      available open-source pipeline for DBS electrode
                      reconstructions in rats. The presented initial validation
                      results are promising.},
      keywords     = {Animals / Axons / Deep Brain Stimulation / Electrodes,
                      Implanted / Magnetic Resonance Imaging / Male / Models,
                      Animal / Models, Neurological / Neuroimaging / Rats /
                      Reproducibility of Results / Software / Ventral Tegmental
                      Area: diagnostic imaging / Animal models (Other) / Deep
                      brain stimulation (Other) / Neuroimaging (Other) /
                      Open-source (Other) / Parkinson's disease (Other) / Rat
                      (Other) / Research software (Other) / Rodent (Other)},
      cin          = {AG Storch 2 Rostock},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35026227},
      doi          = {10.1016/j.expneurol.2022.113978},
      url          = {https://pub.dzne.de/record/163494},
}