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000163503 0247_ $$2doi$$a10.3233/JAD-215196
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000163503 1001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b0$$eFirst author
000163503 245__ $$aAssociation of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum.
000163503 260__ $$aAmsterdam$$bIOS Press$$c2022
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000163503 520__ $$aInflammation has been described as a key pathogenic event in Alzheimer's disease (AD), downstream of amyloid and tau pathology. Preclinical and clinical data suggest that the cholinergic basal forebrain may moderate inflammatory response to different pathologies.To study the association of cholinergic basal forebrain volume and functional connectivity with measures of neuroinflammation in people from the AD spectrum.We studied 261 cases from the DELCODE cohort, including people with subjective cognitive decline, mild cognitive impairment, AD dementia, first degree relatives, and healthy controls. Using Bayesian ANCOVA, we tested associations of MRI indices of cholinergic basal forebrain volume and functional connectivity with cerebrospinal fluid (CSF) levels of sTREM2 as a marker of microglia activation, and serum levels of complement C3. Using Bayesian elastic net regression, we determined associations between basal forebrain measures and a large inflammation marker panel from CSF and serum.We found anecdotal to moderate evidence in favor of the absence of an effect of basal forebrain volume and functional connectivity on CSF sTREM2 and serum C3 levels both in Aβ42/ptau-positive and negative cases. Bayesian elastic net regression identified several CSF and serum markers of inflammation that were associated with basal forebrain volume and functional connectivity. The effect sizes were moderate to small.Our data-driven analyses generate the hypothesis that cholinergic basal forebrain may be involved in the neuroinflammation response to Aβ42 and phospho-tau pathology in people from the AD spectrum. This hypothesis needs to be tested in independent samples.
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000163503 650_7 $$2Other$$aAlzheimer’s disease
000163503 650_7 $$2Other$$aMRI
000163503 650_7 $$2Other$$acerebrospinal fluid
000163503 650_7 $$2Other$$acholinergic system
000163503 650_7 $$2Other$$aneuroinflammation
000163503 650_7 $$2Other$$aplasma
000163503 650_7 $$2Other$$asTREM2
000163503 650_7 $$2NLM Chemicals$$aBiomarkers
000163503 650_7 $$2NLM Chemicals$$aCholinergic Agents
000163503 650_2 $$2MeSH$$aAged
000163503 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000163503 650_2 $$2MeSH$$aBasal Forebrain: pathology
000163503 650_2 $$2MeSH$$aBiomarkers: blood
000163503 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000163503 650_2 $$2MeSH$$aCholinergic Agents
000163503 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000163503 650_2 $$2MeSH$$aCohort Studies
000163503 650_2 $$2MeSH$$aFemale
000163503 650_2 $$2MeSH$$aHumans
000163503 650_2 $$2MeSH$$aInflammation: pathology
000163503 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000163503 650_2 $$2MeSH$$aMale
000163503 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000163503 7001_ $$0P:(DE-2719)2810283$$aDyrba, Martin$$b1
000163503 7001_ $$0P:(DE-2719)9000476$$aBallarini, Tommaso$$b2
000163503 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b3
000163503 7001_ $$0P:(DE-HGF)0$$aBruno, Davide$$b4
000163503 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b5$$udzne
000163503 7001_ $$0P:(DE-HGF)0$$aCosma, Nicoleta-Carmen$$b6
000163503 7001_ $$0P:(DE-HGF)0$$aDechent, Peter$$b7
000163503 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b8
000163503 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b9
000163503 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b10
000163503 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b11
000163503 7001_ $$0P:(DE-HGF)0$$aHaynes, John D$$b12
000163503 7001_ $$0P:(DE-HGF)0$$aJanowitz, Daniel$$b13
000163503 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b14
000163503 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b15
000163503 7001_ $$0P:(DE-HGF)0$$aMaier, Franziska$$b16
000163503 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline D$$b17
000163503 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias H$$b18
000163503 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b19
000163503 7001_ $$0P:(DE-HGF)0$$aPomara, Nunzio$$b20
000163503 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b21
000163503 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b22
000163503 7001_ $$0P:(DE-2719)2812825$$aRamírez, Alfredo$$b23
000163503 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b24
000163503 7001_ $$0P:(DE-HGF)0$$aScheffler, Klaus$$b25
000163503 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b26
000163503 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn H$$b27
000163503 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b28
000163503 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike J$$b29
000163503 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b30
000163503 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b31
000163503 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b32
000163503 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b33$$eLast author
000163503 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-215196$$gVol. 85, no. 3, p. 1267 - 1282$$n3$$p1267 - 1282$$tJournal of Alzheimer's disease$$v85$$x1875-8908$$y2022
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