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@ARTICLE{Teipel:163503,
      author       = {Teipel, Stefan and Dyrba, Martin and Ballarini, Tommaso and
                      Brosseron, Frederic and Bruno, Davide and Bürger, Katharina
                      and Cosma, Nicoleta-Carmen and Dechent, Peter and Dobisch,
                      Laura and Düzel, Emrah and Ewers, Michael and Fliessbach,
                      Klaus and Haynes, John D and Janowitz, Daniel and Kilimann,
                      Ingo and Laske, Christoph and Maier, Franziska and Metzger,
                      Coraline D and Munk, Matthias H and Peters, Oliver and
                      Pomara, Nunzio and Preis, Lukas and Priller, Josef and
                      Ramírez, Alfredo and Roy, Nina and Scheffler, Klaus and
                      Schneider, Anja and Schott, Björn H and Spottke, Annika and
                      Spruth, Eike J and Wagner, Michael and Wiltfang, Jens and
                      Jessen, Frank and Heneka, Michael T},
      title        = {{A}ssociation of {C}holinergic {B}asal {F}orebrain {V}olume
                      and {F}unctional {C}onnectivity with {M}arkers of
                      {I}nflammatory {R}esponse in the {A}lzheimer's {D}isease
                      {S}pectrum.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {85},
      number       = {3},
      issn         = {1875-8908},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2022-00263},
      pages        = {1267 - 1282},
      year         = {2022},
      abstract     = {Inflammation has been described as a key pathogenic event
                      in Alzheimer's disease (AD), downstream of amyloid and tau
                      pathology. Preclinical and clinical data suggest that the
                      cholinergic basal forebrain may moderate inflammatory
                      response to different pathologies.To study the association
                      of cholinergic basal forebrain volume and functional
                      connectivity with measures of neuroinflammation in people
                      from the AD spectrum.We studied 261 cases from the DELCODE
                      cohort, including people with subjective cognitive decline,
                      mild cognitive impairment, AD dementia, first degree
                      relatives, and healthy controls. Using Bayesian ANCOVA, we
                      tested associations of MRI indices of cholinergic basal
                      forebrain volume and functional connectivity with
                      cerebrospinal fluid (CSF) levels of sTREM2 as a marker of
                      microglia activation, and serum levels of complement C3.
                      Using Bayesian elastic net regression, we determined
                      associations between basal forebrain measures and a large
                      inflammation marker panel from CSF and serum.We found
                      anecdotal to moderate evidence in favor of the absence of an
                      effect of basal forebrain volume and functional connectivity
                      on CSF sTREM2 and serum C3 levels both in
                      Aβ42/ptau-positive and negative cases. Bayesian elastic net
                      regression identified several CSF and serum markers of
                      inflammation that were associated with basal forebrain
                      volume and functional connectivity. The effect sizes were
                      moderate to small.Our data-driven analyses generate the
                      hypothesis that cholinergic basal forebrain may be involved
                      in the neuroinflammation response to Aβ42 and phospho-tau
                      pathology in people from the AD spectrum. This hypothesis
                      needs to be tested in independent samples.},
      keywords     = {Aged / Alzheimer Disease: pathology / Basal Forebrain:
                      pathology / Biomarkers: blood / Biomarkers: cerebrospinal
                      fluid / Cholinergic Agents / Cognitive Dysfunction:
                      pathology / Cohort Studies / Female / Humans / Inflammation:
                      pathology / Magnetic Resonance Imaging / Male /
                      Alzheimer’s disease (Other) / MRI (Other) / cerebrospinal
                      fluid (Other) / cholinergic system (Other) /
                      neuroinflammation (Other) / plasma (Other) / sTREM2 (Other)
                      / Biomarkers (NLM Chemicals) / Cholinergic Agents (NLM
                      Chemicals)},
      cin          = {AG Teipel / AG Wagner / Biomarker / AG Speck / AG Simons /
                      Patient Studies Bonn / Core ICRU / Magdeburg common / AG
                      Gasser / AG Endres / AG Priller / Clinical Research Platform
                      (CRP) / AG Schneider / AG Fischer / AG Klockgether / AG
                      Wiltfang / AG Jessen / AG Dichgans / AG Düzel / Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100 / I:(DE-2719)1011201 /
                      I:(DE-2719)1011301 / I:(DE-2719)1340009 / I:(DE-2719)1110008
                      / I:(DE-2719)1011101 / I:(DE-2719)1240005 /
                      I:(DE-2719)6000015 / I:(DE-2719)1210000 / I:(DE-2719)1811005
                      / I:(DE-2719)5000007 / I:(DE-2719)1011401 /
                      I:(DE-2719)1011305 / I:(DE-2719)1410002 / I:(DE-2719)1011001
                      / I:(DE-2719)1410006 / I:(DE-2719)1011102 /
                      I:(DE-2719)5000022 / I:(DE-2719)5000006 /
                      I:(DE-2719)5000034},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 351 -
                      Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34924387},
      doi          = {10.3233/JAD-215196},
      url          = {https://pub.dzne.de/record/163503},
}