TY  - JOUR
AU  - Kizilirmak, Jasmin
AU  - Schott, Björn H
AU  - Thuerich, Hannes
AU  - Sweeney-Reed, Catherine M
AU  - Richter, Anni
AU  - Folta-Schoofs, Kristian
AU  - Richardson-Klavehn, Alan
TI  - Learning of novel semantic relationships via sudden comprehension is associated with a hippocampus-independent network.
JO  - Consciousness and cognition
VL  - 69
SN  - 1053-8100
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2022-00275
SP  - 113 - 132
PY  - 2019
N1  - CC BY-NC-ND
AB  - Sudden comprehension-or insight-during problem-solving can enhance learning, but the underlying neural processes are largely unknown. We investigated neural correlates of learning from sudden comprehension using functional magnetic resonance imaging and a verbal problem-solving task. Solutions and 'solutions' to solvable and unsolvable verbal problems, respectively, were presented to induce sudden comprehension or continued incomprehension. We found activations of the hippocampus, medial prefrontal cortex (mPFC), amygdala, and striatum during sudden comprehension. Notably, however, mPFC and temporo-parietal neocortical structures rather than the hippocampus were associated with later learning of suddenly comprehended solutions. Moreover, difficult compared to easy sudden comprehension elicited midbrain activations and was associated with successful learning, pointing to learning via intrinsic reward. Sudden comprehension of novel semantic associations may constitute a special case of long-term memory formation primarily mediated by the mPFC, expanding our knowledge of its role in prior-knowledge-dependent memory.
KW  - Adult
KW  - Association
KW  - Comprehension: physiology
KW  - Female
KW  - Hippocampus: diagnostic imaging
KW  - Hippocampus: physiology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory, Long-Term: physiology
KW  - Prefrontal Cortex: diagnostic imaging
KW  - Prefrontal Cortex: physiology
KW  - Problem Solving: physiology
KW  - Semantics
KW  - Young Adult
KW  - Encoding (Other)
KW  - Hippocampus (Other)
KW  - Insight (Other)
KW  - Learning (Other)
KW  - Long-term memory (Other)
KW  - Problem solving (Other)
KW  - Semantic memory (Other)
KW  - Sudden comprehension (Other)
KW  - fMRI (Other)
KW  - mPFC (Other)
LB  - PUB:(DE-HGF)36 ; PUB:(DE-HGF)16
C6  - pmid:30763808
DO  - DOI:10.1016/j.concog.2019.01.005
UR  - https://pub.dzne.de/record/163515
ER  -