Review/Journal Article

DZNE-2022-00275

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Learning of novel semantic relationships via sudden comprehension is associated with a hippocampus-independent network.

Kizilirmak, J. (First author)Extern* ; Schott, B. H.Extern* ; Thuerich, H. ; Sweeney-Reed, C. M. ; Richter, A. ; Folta-Schoofs, K. ; Richardson-Klavehn, A. (Last author)

2019
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.concog.2019.01.005

Abstract: Sudden comprehension-or insight-during problem-solving can enhance learning, but the underlying neural processes are largely unknown. We investigated neural correlates of learning from sudden comprehension using functional magnetic resonance imaging and a verbal problem-solving task. Solutions and 'solutions' to solvable and unsolvable verbal problems, respectively, were presented to induce sudden comprehension or continued incomprehension. We found activations of the hippocampus, medial prefrontal cortex (mPFC), amygdala, and striatum during sudden comprehension. Notably, however, mPFC and temporo-parietal neocortical structures rather than the hippocampus were associated with later learning of suddenly comprehended solutions. Moreover, difficult compared to easy sudden comprehension elicited midbrain activations and was associated with successful learning, pointing to learning via intrinsic reward. Sudden comprehension of novel semantic associations may constitute a special case of long-term memory formation primarily mediated by the mPFC, expanding our knowledge of its role in prior-knowledge-dependent memory.

Keyword(s): Adult (MeSH) ; Association (MeSH) ; Comprehension: physiology (MeSH) ; Female (MeSH) ; Hippocampus: diagnostic imaging (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Memory, Long-Term: physiology (MeSH) ; Prefrontal Cortex: diagnostic imaging (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Problem Solving: physiology (MeSH) ; Semantics (MeSH) ; Young Adult (MeSH) ; Encoding ; Hippocampus ; Insight ; Learning ; Long-term memory ; Problem solving ; Semantic memory ; Sudden comprehension ; fMRI ; mPFC

Note: CC BY-NC-ND

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Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; Hosted Content ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Social Sciences Citation Index

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