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@ARTICLE{Kizilirmak:163515,
author = {Kizilirmak, Jasmin and Schott, Björn H and Thuerich,
Hannes and Sweeney-Reed, Catherine M and Richter, Anni and
Folta-Schoofs, Kristian and Richardson-Klavehn, Alan},
title = {{L}earning of novel semantic relationships via sudden
comprehension is associated with a hippocampus-independent
network.},
journal = {Consciousness and cognition},
volume = {69},
issn = {1053-8100},
address = {Orlando, Fla.},
publisher = {Academic Press},
reportid = {DZNE-2022-00275},
pages = {113 - 132},
year = {2019},
note = {CC BY-NC-ND},
abstract = {Sudden comprehension-or insight-during problem-solving can
enhance learning, but the underlying neural processes are
largely unknown. We investigated neural correlates of
learning from sudden comprehension using functional magnetic
resonance imaging and a verbal problem-solving task.
Solutions and 'solutions' to solvable and unsolvable verbal
problems, respectively, were presented to induce sudden
comprehension or continued incomprehension. We found
activations of the hippocampus, medial prefrontal cortex
(mPFC), amygdala, and striatum during sudden comprehension.
Notably, however, mPFC and temporo-parietal neocortical
structures rather than the hippocampus were associated with
later learning of suddenly comprehended solutions. Moreover,
difficult compared to easy sudden comprehension elicited
midbrain activations and was associated with successful
learning, pointing to learning via intrinsic reward. Sudden
comprehension of novel semantic associations may constitute
a special case of long-term memory formation primarily
mediated by the mPFC, expanding our knowledge of its role in
prior-knowledge-dependent memory.},
keywords = {Adult / Association / Comprehension: physiology / Female /
Hippocampus: diagnostic imaging / Hippocampus: physiology /
Humans / Magnetic Resonance Imaging / Male / Memory,
Long-Term: physiology / Prefrontal Cortex: diagnostic
imaging / Prefrontal Cortex: physiology / Problem Solving:
physiology / Semantics / Young Adult / Encoding (Other) /
Hippocampus (Other) / Insight (Other) / Learning (Other) /
Long-term memory (Other) / Problem solving (Other) /
Semantic memory (Other) / Sudden comprehension (Other) /
fMRI (Other) / mPFC (Other)},
ddc = {150},
pnm = {353 - Clinical and Health Care Research (POF4-353) / 352 -
Disease Mechanisms (POF4-352)},
pid = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
typ = {PUB:(DE-HGF)36 / PUB:(DE-HGF)16},
pubmed = {pmid:30763808},
doi = {10.1016/j.concog.2019.01.005},
url = {https://pub.dzne.de/record/163515},
}