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@ARTICLE{Atrsaei:163540,
      author       = {Atrsaei, Arash and Hansen, Clint and Elshehabi, Morad and
                      Nußbaum, Susanne and Berg, Daniela and Liepelt-Scarfone,
                      Inga and Maetzler, Walter and Aminian, Kamiar},
      title        = {{E}ffect of {F}ear of {F}alling on {M}obility {M}easured
                      {D}uring {L}ab and {D}aily {A}ctivity {A}ssessments in
                      {P}arkinson's {D}isease.},
      journal      = {Frontiers in aging neuroscience},
      volume       = {13},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2022-00300},
      pages        = {722830},
      year         = {2021},
      abstract     = {In chronic disorders such as Parkinson's disease (PD), fear
                      of falling (FOF) is associated with falls and reduced
                      quality of life. With inertial measurement units (IMUs) and
                      dedicated algorithms, different aspects of mobility can be
                      obtained during supervised tests in the lab and also during
                      daily activities. To our best knowledge, the effect of FOF
                      on mobility has not been investigated in both of these
                      settings simultaneously. Our goal was to evaluate the effect
                      of FOF on the mobility of 26 patients with PD during
                      clinical assessments and 14 days of daily activity
                      monitoring. Parameters related to gait, sit-to-stand
                      transitions, and turns were extracted from IMU signals on
                      the lower back. Fear of falling was assessed using the Falls
                      Efficacy Scale-International (FES-I) and the patients were
                      grouped as with (PD-FOF+) and without FOF (PD-FOF-).
                      Mobility parameters between groups were compared using
                      logistic regression as well as the effect size values
                      obtained using the Wilcoxon rank-sum test. The peak angular
                      velocity of the turn-to-sit transition of the
                      timed-up-and-go (TUG) test had the highest discriminative
                      power between PD-FOF+ and PD-FOF- (r-value of effect size =
                      0.61). Moreover, PD-FOF+ had a tendency toward lower gait
                      speed at home and a lower amount of walking bouts,
                      especially for shorter walking bouts. The combination of lab
                      and daily activity parameters reached a higher
                      discriminative power [area under the curve (AUC) = 0.75]
                      than each setting alone (AUC = 0.68 in the lab, AUC = 0.54
                      at home). Comparing the gait speed between the two
                      assessments, the PD-FOF+ showed higher gait speeds in the
                      capacity area compared with their TUG test in the lab. The
                      mobility parameters extracted from both lab and home-based
                      assessments contribute to the detection of FOF in PD. This
                      study adds further evidence to the usefulness of mobility
                      assessments that include different environments and
                      assessment strategies. Although this study was limited in
                      the sample size, it still provides a helpful method to
                      consider the daily activity measurement of the patients with
                      PD into clinical evaluation. The obtained results can help
                      the clinicians with a more accurate prevention and treatment
                      strategy.},
      keywords     = {gait (Other) / inertial sensor (Other) / sit-to-stand
                      (Other) / timed-up and go (Other) / turning (Other) /
                      wearables (Other)},
      cin          = {AG Berg / Core ICRU / AG Gasser 2 ; AG Gasser 2},
      ddc          = {610},
      cid          = {I:(DE-2719)5000055 / I:(DE-2719)1240005 /
                      I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34916920},
      pmc          = {pmc:PMC8669821},
      doi          = {10.3389/fnagi.2021.722830},
      url          = {https://pub.dzne.de/record/163540},
}