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@ARTICLE{Bendig:163594,
      author       = {Bendig, Jonas and Wolf, Hanna and Mark, Tony and Frank,
                      Anika and Mathiebe, Josephine and Scheibe, Madlen and
                      Müller, Gabriele and Stahr, Marcus and Schmitt, Jochen and
                      Reichmann, Heinz and Loewenbrück, Kai F. and Falkenburger,
                      Björn H.},
      title        = {{F}easibility of a {M}ultimodal {T}elemedical
                      {I}ntervention for {P}atients with {P}arkinson’s
                      {D}isease—{A} {P}ilot {S}tudy},
      journal      = {Journal of Clinical Medicine},
      volume       = {11},
      number       = {4},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2022-00340},
      pages        = {1074},
      year         = {2022},
      abstract     = {Symptoms of Parkinson's disease (PD) can be controlled
                      well, but treatment often requires expert judgment.
                      Telemedicine and sensor-based assessments can allow
                      physicians to better observe the evolvement of symptoms over
                      time, in particular with motor fluctuations. In addition,
                      they potentially allow less frequent visits to the expert's
                      office and facilitate care in rural areas. A variety of
                      systems with different strengths and shortcomings has been
                      investigated in recent years. We designed a multimodal
                      telehealth intervention (TelePark) to mitigate the
                      shortcomings of individual systems and assessed the
                      feasibility of our approach in 12 patients with PD over 12
                      weeks in preparation for a larger randomized controlled
                      trial. TelePark uses video visits, a smartphone app, a
                      camera system, and wearable sensors. Structured training
                      included setting up the equipment in patients' homes and
                      group-based online training. Usability was assessed by
                      questionnaires and semi-standardized telephone interviews.
                      Overall, 11 out of 12 patients completed the trial (5
                      female, 6 male). Mean age was 65 years, mean disease
                      duration 7 years, mean MoCA score 27. Adherence was stable
                      throughout the study and $79\%$ for a short questionnaire
                      administered every second day, $62\%$ for medication
                      confirmation, and $33\%$ for an electronic Hauser diary.
                      Quality of life did not change in the course of the study,
                      and a larger cohort will be required to determine the effect
                      on motor symptoms. Interviews with trial participants
                      identified motivations to use such systems and areas for
                      improvements. These insights can be helpful in designing
                      similar trials.},
      cin          = {Clinical Study Team Dresden ; AG Falkenburger / AG Donix /
                      AG Kempermann 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1710012 / I:(DE-2719)1710008 /
                      I:(DE-2719)1710001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35207351},
      pmc          = {pmc:PMC8875136},
      doi          = {10.3390/jcm11041074},
      url          = {https://pub.dzne.de/record/163594},
}