TY  - JOUR
AU  - Obrecht, Denise
AU  - Mynarek, Martin
AU  - Hagel, Christian
AU  - Kwiecien, Robert
AU  - Spohn, Michael
AU  - Bockmayr, Michael
AU  - Bison, Brigitte
AU  - Pfister, Stefan M
AU  - Jones, David T W
AU  - Sturm, Dominik
AU  - von Deimling, Andreas
AU  - Sahm, Felix
AU  - von Hoff, Katja
AU  - Juhnke, B-Ole
AU  - Benesch, Martin
AU  - Gerber, Nicolas U
AU  - Friedrich, Carsten
AU  - von Bueren, André O
AU  - Kortmann, Rolf-Dieter
AU  - Schwarz, Rudolf
AU  - Pietsch, Torsten
AU  - Fleischhack, Gudrun
AU  - Schüller, Ulrich
AU  - Rutkowski, Stefan
TI  - Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies.
JO  - Journal of neuro-oncology
VL  - 157
IS  - 1
SN  - 0167-594X
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DZNE-2022-00354
SP  - 37 - 48
PY  - 2022
N1  - (CC BY)
AB  - To evaluate the clinical impact of isolated spread of medulloblastoma cells into cerebrospinal fluid without additional macroscopic metastases (M1-only).The HIT-MED database was searched for pediatric patients with M1-only medulloblastoma diagnosed from 2000 to 2019. Corresponding clinical and molecular data was evaluated. Treatment was stratified by age and changed over time for older patients.70 patients with centrally reviewed M1-only disease were identified. Clinical data was available for all and molecular data for 45/70 cases. 91
KW  - Cerebellar Neoplasms: drug therapy
KW  - Cerebellar Neoplasms: therapy
KW  - Child
KW  - Craniospinal Irradiation
KW  - Humans
KW  - Medulloblastoma: drug therapy
KW  - Medulloblastoma: therapy
KW  - Risk Factors
KW  - Cerebrospinal fluid (Other)
KW  - Children (Other)
KW  - Medulloblastoma (Other)
KW  - Metastases (Other)
KW  - Radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35190934
C2  - pmc:PMC8938370
DO  - DOI:10.1007/s11060-021-03913-5
UR  - https://pub.dzne.de/record/163608
ER  -