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000163623 0247_ $$2doi$$a10.3389/fgene.2021.812139
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000163623 1001_ $$aHeinen, Tobias$$b0
000163623 245__ $$aEvolution of a New Testis-Specific Functional Promoter Within the Highly Conserved Map2k7 Gene of the Mouse.
000163623 260__ $$aLausanne$$bFrontiers Media$$c2022
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000163623 520__ $$aMap2k7 (synonym Mkk7) is a conserved regulatory kinase gene and a central component of the JNK signaling cascade with key functions during cellular differentiation. It shows complex transcription patterns, and different transcript isoforms are known in the mouse (Mus musculus). We have previously identified a newly evolved testis-specific transcript for the Map2k7 gene in the subspecies M. m. domesticus. Here, we identify the new promoter that drives this transcript and find that it codes for an open reading frame (ORF) of 50 amino acids. The new promoter was gained in the stem lineage of closely related mouse species but was secondarily lost in the subspecies M. m. musculus and M. m. castaneus. A single mutation can be correlated with its transcriptional activity in M. m. domesticus, and cell culture assays demonstrate the capability of this mutation to drive expression. A mouse knockout line in which the promoter region of the new transcript is deleted reveals a functional contribution of the newly evolved promoter to sperm motility and the spermatid transcriptome. Our data show that a new functional transcript (and possibly protein) can evolve within an otherwise highly conserved gene, supporting the notion of regulatory changes contributing to the emergence of evolutionary novelties.
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000163623 650_7 $$2Other$$akinase
000163623 650_7 $$2Other$$anew promotor
000163623 650_7 $$2Other$$aregulatory evolution
000163623 650_7 $$2Other$$asperm maturation
000163623 650_7 $$2Other$$atestis
000163623 693__ $$0EXP:(DE-2719)LAT-20190308$$5EXP:(DE-2719)LAT-20190308$$eLaboratory Automation Technologies (CRFS-LAT) / Bonn$$x0
000163623 7001_ $$aXie, Chen$$b1
000163623 7001_ $$0P:(DE-2719)9001816$$aKeshavarz, Maryam$$b2$$udzne
000163623 7001_ $$0P:(DE-2719)2812160$$aStappert, Dominik$$b3$$udzne
000163623 7001_ $$aKünzel, Sven$$b4
000163623 7001_ $$aTautz, Diethard$$b5
000163623 773__ $$0PERI:(DE-600)2606823-0$$a10.3389/fgene.2021.812139$$gVol. 12, p. 812139$$p812139$$tFrontiers in genetics$$v12$$x1664-8021$$y2022
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