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@ARTICLE{Dankovich:163625,
      author       = {Dankovich, Tal M and Kaushik, Rahul and Olsthoorn, Linda H
                      M and Petersen, Gabriel Cassinelli and Giro, Philipp Emanuel
                      and Kluever, Verena and Agüi-Gonzalez, Paola and Grewe,
                      Katharina and Bao, Guobin and Beuermann, Sabine and Hadi,
                      Hannah Abdul and Doeren, Jose and Klöppner, Simon and
                      Cooper, Benjamin H and Dityatev, Alexander and Rizzoli,
                      Silvio O},
      title        = {{E}xtracellular matrix remodeling through endocytosis and
                      resurfacing of {T}enascin-{R}.},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2022-00371},
      pages        = {7129},
      year         = {2021},
      abstract     = {The brain extracellular matrix (ECM) consists of extremely
                      long-lived proteins that assemble around neurons and
                      synapses, to stabilize them. The ECM is thought to change
                      only rarely, in relation to neuronal plasticity, through ECM
                      proteolysis and renewed protein synthesis. We report here an
                      alternative ECM remodeling mechanism, based on the recycling
                      of ECM molecules. Using multiple ECM labeling and imaging
                      assays, from super-resolution optical imaging to nanoscale
                      secondary ion mass spectrometry, both in culture and in
                      brain slices, we find that a key ECM protein, Tenascin-R, is
                      frequently endocytosed, and later resurfaces, preferentially
                      near synapses. The TNR molecules complete this cycle within
                      ~3 days, in an activity-dependent fashion. Interfering with
                      the recycling process perturbs severely neuronal function,
                      strongly reducing synaptic vesicle exo- and endocytosis. We
                      conclude that the neuronal ECM can be remodeled frequently
                      through mechanisms that involve endocytosis and recycling of
                      ECM proteins.},
      keywords     = {Animals / Brain: metabolism / Endocytosis / Epitopes /
                      Extracellular Matrix: metabolism / Extracellular Matrix
                      Proteins: metabolism / Golgi Apparatus / Male / Membrane
                      Transport Proteins: metabolism / Mice / Mice, Inbred C57BL /
                      Neuronal Plasticity: physiology / Neurons: metabolism /
                      Synapses: metabolism / Tenascin: metabolism / Epitopes (NLM
                      Chemicals) / Extracellular Matrix Proteins (NLM Chemicals) /
                      Membrane Transport Proteins (NLM Chemicals) / Tenascin (NLM
                      Chemicals) / tenascin R (NLM Chemicals)},
      cin          = {AG Dityatev},
      ddc          = {500},
      cid          = {I:(DE-2719)1310007},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34880248},
      pmc          = {pmc:PMC8654841},
      doi          = {10.1038/s41467-021-27462-7},
      url          = {https://pub.dzne.de/record/163625},
}