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001     163625
005     20230915092425.0
024 7 _ |a 10.1038/s41467-021-27462-7
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041 _ _ |a English
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100 1 _ |a Dankovich, Tal M
|0 0000-0003-4757-9462
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245 _ _ |a Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R.
260 _ _ |a [London]
|c 2021
|b Nature Publishing Group UK
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520 _ _ |a The brain extracellular matrix (ECM) consists of extremely long-lived proteins that assemble around neurons and synapses, to stabilize them. The ECM is thought to change only rarely, in relation to neuronal plasticity, through ECM proteolysis and renewed protein synthesis. We report here an alternative ECM remodeling mechanism, based on the recycling of ECM molecules. Using multiple ECM labeling and imaging assays, from super-resolution optical imaging to nanoscale secondary ion mass spectrometry, both in culture and in brain slices, we find that a key ECM protein, Tenascin-R, is frequently endocytosed, and later resurfaces, preferentially near synapses. The TNR molecules complete this cycle within ~3 days, in an activity-dependent fashion. Interfering with the recycling process perturbs severely neuronal function, strongly reducing synaptic vesicle exo- and endocytosis. We conclude that the neuronal ECM can be remodeled frequently through mechanisms that involve endocytosis and recycling of ECM proteins.
536 _ _ |a 351 - Brain Function (POF4-351)
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650 _ 7 |a Epitopes
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650 _ 7 |a Extracellular Matrix Proteins
|2 NLM Chemicals
650 _ 7 |a Membrane Transport Proteins
|2 NLM Chemicals
650 _ 7 |a Tenascin
|2 NLM Chemicals
650 _ 7 |a tenascin R
|0 147604-77-1
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Endocytosis
|2 MeSH
650 _ 2 |a Epitopes
|2 MeSH
650 _ 2 |a Extracellular Matrix: metabolism
|2 MeSH
650 _ 2 |a Extracellular Matrix Proteins: metabolism
|2 MeSH
650 _ 2 |a Golgi Apparatus
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Membrane Transport Proteins: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Synapses: metabolism
|2 MeSH
650 _ 2 |a Tenascin: metabolism
|2 MeSH
700 1 _ |a Kaushik, Rahul
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700 1 _ |a Olsthoorn, Linda H M
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700 1 _ |a Petersen, Gabriel Cassinelli
|0 0000-0002-4546-0567
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700 1 _ |a Giro, Philipp Emanuel
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700 1 _ |a Kluever, Verena
|0 0000-0002-0505-8231
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700 1 _ |a Agüi-Gonzalez, Paola
|0 0000-0002-2313-1439
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700 1 _ |a Grewe, Katharina
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700 1 _ |a Bao, Guobin
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700 1 _ |a Beuermann, Sabine
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700 1 _ |a Hadi, Hannah Abdul
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700 1 _ |a Doeren, Jose
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700 1 _ |a Klöppner, Simon
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700 1 _ |a Cooper, Benjamin H
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700 1 _ |a Dityatev, Alexander
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700 1 _ |a Rizzoli, Silvio O
|0 0000-0002-1667-7839
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773 _ _ |a 10.1038/s41467-021-27462-7
|g Vol. 12, no. 1, p. 7129
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|t Nature Communications
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