000163640 001__ 163640
000163640 005__ 20231027131220.0
000163640 0247_ $$2doi$$a10.1038/s41556-021-00774-y
000163640 0247_ $$2pmid$$apmid:34876685
000163640 0247_ $$2pmc$$apmc:PMC8683376
000163640 0247_ $$2ISSN$$a1465-7392
000163640 0247_ $$2ISSN$$a1476-4679
000163640 0247_ $$2altmetric$$aaltmetric:118324437
000163640 037__ $$aDZNE-2022-00386
000163640 041__ $$aEnglish
000163640 082__ $$a570
000163640 1001_ $$0P:(DE-2719)9002262$$aGerber, Julia P$$b0$$eFirst author$$udzne
000163640 245__ $$aAberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.
000163640 260__ $$aNew York, NY$$bNature America$$c2021
000163640 3367_ $$2DRIVER$$aarticle
000163640 3367_ $$2DataCite$$aOutput Types/Journal article
000163640 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1698329658_2087
000163640 3367_ $$2BibTeX$$aARTICLE
000163640 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000163640 3367_ $$00$$2EndNote$$aJournal Article
000163640 520__ $$aDefective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx alters the chromatin landscape, H3.3 distribution and histone marks of haematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional programme for myelopoiesis at the expense of B-cell differentiation. This causes neutrophilia and inflammation, predisposing mice to develop an autoinflammatory skin disease. While these molecular and phenotypic perturbations are in part reverted in animals lacking both Pu.1 and Daxx, haematopoietic progenitors in these mice show unique chromatin and transcriptome alterations, suggesting an interaction between these two pathways. Overall, our findings implicate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1.
000163640 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000163640 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x1
000163640 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x2
000163640 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000163640 650_7 $$2NLM Chemicals$$aChromatin
000163640 650_7 $$2NLM Chemicals$$aCo-Repressor Proteins
000163640 650_7 $$2NLM Chemicals$$aDaxx protein, mouse
000163640 650_7 $$2NLM Chemicals$$aHistones
000163640 650_7 $$2NLM Chemicals$$aMolecular Chaperones
000163640 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins
000163640 650_7 $$2NLM Chemicals$$aRetroelements
000163640 650_7 $$2NLM Chemicals$$aTrans-Activators
000163640 650_7 $$2NLM Chemicals$$aproto-oncogene protein Spi-1
000163640 650_2 $$2MeSH$$aAnimals
000163640 650_2 $$2MeSH$$aAutoimmune Diseases: genetics
000163640 650_2 $$2MeSH$$aAutoimmune Diseases: pathology
000163640 650_2 $$2MeSH$$aB-Lymphocytes: cytology
000163640 650_2 $$2MeSH$$aCell Line
000163640 650_2 $$2MeSH$$aChromatin: genetics
000163640 650_2 $$2MeSH$$aChromatin: pathology
000163640 650_2 $$2MeSH$$aCo-Repressor Proteins: genetics
000163640 650_2 $$2MeSH$$aHematopoietic Stem Cells: cytology
000163640 650_2 $$2MeSH$$aHistones: metabolism
000163640 650_2 $$2MeSH$$aHumans
000163640 650_2 $$2MeSH$$aInflammation: pathology
000163640 650_2 $$2MeSH$$aLeukocyte Disorders: congenital
000163640 650_2 $$2MeSH$$aLeukocyte Disorders: pathology
000163640 650_2 $$2MeSH$$aMice
000163640 650_2 $$2MeSH$$aMice, Inbred C57BL
000163640 650_2 $$2MeSH$$aMice, Knockout
000163640 650_2 $$2MeSH$$aMolecular Chaperones: genetics
000163640 650_2 $$2MeSH$$aMyelopoiesis: genetics
000163640 650_2 $$2MeSH$$aProto-Oncogene Proteins: metabolism
000163640 650_2 $$2MeSH$$aRetroelements: genetics
000163640 650_2 $$2MeSH$$aSkin Diseases: genetics
000163640 650_2 $$2MeSH$$aSkin Diseases: immunology
000163640 650_2 $$2MeSH$$aSkin Diseases: pathology
000163640 650_2 $$2MeSH$$aTrans-Activators: metabolism
000163640 7001_ $$0P:(DE-2719)2812322$$aRuss, Jenny$$b1$$eFirst author
000163640 7001_ $$0P:(DE-2719)2812573$$aChandrasekar, Vijay$$b2
000163640 7001_ $$0P:(DE-2719)2811777$$aOffermann, Nina$$b3
000163640 7001_ $$0P:(DE-2719)2814197$$aLee, Hang-Mao$$b4
000163640 7001_ $$aSpear, Sarah$$b5
000163640 7001_ $$aGuzzi, Nicola$$b6
000163640 7001_ $$0P:(DE-2719)2158371$$aMaida, Simona$$b7
000163640 7001_ $$0P:(DE-2719)9001263$$aPattabiraman, Sundararaghavan$$b8
000163640 7001_ $$0P:(DE-2719)2812727$$aZhang, Ruoyu$$b9
000163640 7001_ $$aKayvanjoo, Amir H$$b10
000163640 7001_ $$aDatta, Preeta$$b11
000163640 7001_ $$aKasturiarachchi, Jagath$$b12
000163640 7001_ $$0P:(DE-2719)9000774$$aSposito, Teresa$$b13
000163640 7001_ $$aIzotova, Natalia$$b14
000163640 7001_ $$0P:(DE-2719)2812735$$aHändler, Kristian$$b15
000163640 7001_ $$00000-0002-0684-1770$$aAdams, Peter D$$b16
000163640 7001_ $$aMarafioti, Teresa$$b17
000163640 7001_ $$00000-0002-0866-6443$$aEnver, Tariq$$b18
000163640 7001_ $$aWenzel, Jörg$$b19
000163640 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc-Daniel$$b20
000163640 7001_ $$aMass, Elvira$$b21
000163640 7001_ $$00000-0001-8047-5329$$aBellodi, Cristian$$b22
000163640 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim$$b23
000163640 7001_ $$0P:(DE-2719)2811780$$aCapasso, Melania$$b24
000163640 7001_ $$aNimmo, Rachael$$b25
000163640 7001_ $$0P:(DE-2719)2811779$$aSalomoni, Paolo$$b26$$eLast author
000163640 773__ $$0PERI:(DE-600)1494945-3$$a10.1038/s41556-021-00774-y$$gVol. 23, no. 12, p. 1224 - 1239$$n12$$p1224 - 1239$$tNature cell biology$$v23$$x1465-7392$$y2021
000163640 8564_ $$uhttps://pub.dzne.de/record/163640/files/DZNE-2022-00386.pdf$$yOpenAccess
000163640 8564_ $$uhttps://pub.dzne.de/record/163640/files/DZNE-2022-00386.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000163640 909CO $$ooai:pub.dzne.de:163640$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002262$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812322$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812573$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811777$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814197$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2158371$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001263$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812727$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000774$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812735$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812219$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811660$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b23$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811780$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b24$$kDZNE
000163640 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811779$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b26$$kDZNE
000163640 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000163640 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x1
000163640 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x2
000163640 9141_ $$y2021
000163640 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000163640 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-03
000163640 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT CELL BIOL : 2021$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000163640 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000163640 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)9925$$2StatID$$aIF >= 25$$bNAT CELL BIOL : 2021$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-11
000163640 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-11
000163640 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000163640 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2022-11-11$$wger
000163640 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-11
000163640 9201_ $$0I:(DE-2719)1013032$$kAG Salomoni$$lNuclear Function in CNS Pathophysiology$$x0
000163640 9201_ $$0I:(DE-2719)1013031$$kSchultze - PRECISE$$lPlatform for Single Cell Genomics and Epigenomics$$x1
000163640 9201_ $$0I:(DE-2719)5000031$$kR&D PRECISE$$lPlatform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn$$x2
000163640 9201_ $$0I:(DE-2719)1013033$$kAG Capasso$$lImmune Regulation$$x3
000163640 9201_ $$0I:(DE-2719)1013003$$kAG Bano$$lAging and Neurodegeneration$$x4
000163640 9201_ $$0I:(DE-2719)1013035$$kAG Beyer$$lImmunogenomics and Neurodegeneration$$x5
000163640 980__ $$ajournal
000163640 980__ $$aVDB
000163640 980__ $$aUNRESTRICTED
000163640 980__ $$aI:(DE-2719)1013032
000163640 980__ $$aI:(DE-2719)1013031
000163640 980__ $$aI:(DE-2719)5000031
000163640 980__ $$aI:(DE-2719)1013033
000163640 980__ $$aI:(DE-2719)1013003
000163640 980__ $$aI:(DE-2719)1013035
000163640 9801_ $$aFullTexts