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000163653 1001_ $$aEbert, Max L A$$b0
000163653 245__ $$aAnimal Models of Neointimal Hyperplasia and Restenosis: Species-Specific Differences and Implications for Translational Research.
000163653 260__ $$aWashington, DC$$bAmerican College of Cardiology$$c2021
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000163653 520__ $$aThe process of restenosis is based on the interplay of various mechanical and biological processes triggered by angioplasty-induced vascular trauma. Early arterial recoil, negative vascular remodeling, and neointimal formation therefore limit the long-term patency of interventional recanalization procedures. The most serious of these processes is neointimal hyperplasia, which can be traced back to 4 main mechanisms: endothelial damage and activation; monocyte accumulation in the subintimal space; fibroblast migration; and the transformation of vascular smooth muscle cells. A wide variety of animal models exists to investigate the underlying pathophysiology. Although mouse models, with their ease of genetic manipulation, enable cell- and molecular-focused fundamental research, and rats provide the opportunity to use stent and balloon models with high throughput, both rodents lack a lipid metabolism comparable to humans. Rabbits instead build a bridge to close the gap between basic and clinical research due to their human-like lipid metabolism, as well as their size being accessible for clinical angioplasty procedures. Every different combination of animal, dietary, and injury model has various advantages and disadvantages, and the decision for a proper model requires awareness of species-specific biological properties reaching from vessel morphology to distinct cellular and molecular features.
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000163653 650_7 $$2Other$$aApo, apolipoprotein
000163653 650_7 $$2Other$$aCETP, cholesteryl ester transferase protein
000163653 650_7 $$2Other$$aECM, extracellular matrix
000163653 650_7 $$2Other$$aFGF, fibroblast growth factor
000163653 650_7 $$2Other$$aHDL, high-density lipoprotein
000163653 650_7 $$2Other$$aLDL, low-density lipoprotein
000163653 650_7 $$2Other$$aLDLr, LDL receptor
000163653 650_7 $$2Other$$aPDGF, platelet-derived growth factor
000163653 650_7 $$2Other$$aTGF, transforming growth factor
000163653 650_7 $$2Other$$aVLDL, very low-density lipoprotein
000163653 650_7 $$2Other$$aVSMC, vascular smooth muscle cell
000163653 650_7 $$2Other$$aangioplasty
000163653 650_7 $$2Other$$aanimal model
000163653 650_7 $$2Other$$aneointimal hyperplasia
000163653 650_7 $$2Other$$arestenosis
000163653 7001_ $$aSchmidt, Vanessa F$$b1
000163653 7001_ $$aPfaff, Lena$$b2
000163653 7001_ $$0P:(DE-2719)9000925$$avon Thaden, Anne$$b3$$udzne
000163653 7001_ $$aKimm, Melanie A$$b4
000163653 7001_ $$aWildgruber, Moritz$$b5
000163653 773__ $$0PERI:(DE-600)2865010-4$$a10.1016/j.jacbts.2021.06.006$$gVol. 6, no. 11, p. 900 - 917$$n11$$p900 - 917$$tJACC Basic to translational science$$v6$$x2452-302X$$y2021
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