% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ebert:163653,
      author       = {Ebert, Max L A and Schmidt, Vanessa F and Pfaff, Lena and
                      von Thaden, Anne and Kimm, Melanie A and Wildgruber, Moritz},
      title        = {{A}nimal {M}odels of {N}eointimal {H}yperplasia and
                      {R}estenosis: {S}pecies-{S}pecific {D}ifferences and
                      {I}mplications for {T}ranslational {R}esearch.},
      journal      = {JACC Basic to translational science},
      volume       = {6},
      number       = {11},
      issn         = {2452-302X},
      address      = {Washington, DC},
      publisher    = {American College of Cardiology},
      reportid     = {DZNE-2022-00399},
      pages        = {900 - 917},
      year         = {2021},
      abstract     = {The process of restenosis is based on the interplay of
                      various mechanical and biological processes triggered by
                      angioplasty-induced vascular trauma. Early arterial recoil,
                      negative vascular remodeling, and neointimal formation
                      therefore limit the long-term patency of interventional
                      recanalization procedures. The most serious of these
                      processes is neointimal hyperplasia, which can be traced
                      back to 4 main mechanisms: endothelial damage and
                      activation; monocyte accumulation in the subintimal space;
                      fibroblast migration; and the transformation of vascular
                      smooth muscle cells. A wide variety of animal models exists
                      to investigate the underlying pathophysiology. Although
                      mouse models, with their ease of genetic manipulation,
                      enable cell- and molecular-focused fundamental research, and
                      rats provide the opportunity to use stent and balloon models
                      with high throughput, both rodents lack a lipid metabolism
                      comparable to humans. Rabbits instead build a bridge to
                      close the gap between basic and clinical research due to
                      their human-like lipid metabolism, as well as their size
                      being accessible for clinical angioplasty procedures. Every
                      different combination of animal, dietary, and injury model
                      has various advantages and disadvantages, and the decision
                      for a proper model requires awareness of species-specific
                      biological properties reaching from vessel morphology to
                      distinct cellular and molecular features.},
      subtyp        = {Review Article},
      keywords     = {Apo, apolipoprotein (Other) / CETP, cholesteryl ester
                      transferase protein (Other) / ECM, extracellular matrix
                      (Other) / FGF, fibroblast growth factor (Other) / HDL,
                      high-density lipoprotein (Other) / LDL, low-density
                      lipoprotein (Other) / LDLr, LDL receptor (Other) / PDGF,
                      platelet-derived growth factor (Other) / TGF, transforming
                      growth factor (Other) / VLDL, very low-density lipoprotein
                      (Other) / VSMC, vascular smooth muscle cell (Other) /
                      angioplasty (Other) / animal model (Other) / neointimal
                      hyperplasia (Other) / restenosis (Other)},
      cin          = {Animal Facility (Mouse) München},
      ddc          = {610},
      cid          = {I:(DE-2719)1140012},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34869956},
      pmc          = {pmc:PMC8617545},
      doi          = {10.1016/j.jacbts.2021.06.006},
      url          = {https://pub.dzne.de/record/163653},
}