TY  - JOUR
AU  - Mourtzi, N.
AU  - Hatzimanolis, A.
AU  - Xiromerisiou, G.
AU  - Ntanasi, E.
AU  - Georgakis, M. K.
AU  - Ramirez, A.
AU  - Heilmann-Heimbach, S.
AU  - Grenier-Boley, B.
AU  - Lambert, J. C.
AU  - Yannakoulia, M.
AU  - Kosmidis, M.
AU  - Dardiotis, E.
AU  - Hadjigeorgiou, G.
AU  - Sakka, P.
AU  - Scarmeas, N.
TI  - Association between 9p21-23 Locus and Frailty in a Community-Dwelling Greek Population: Results from the Hellenic Longitudinal Investigation of Ageing and Diet.
JO  - The journal of prevention of Alzheimer's disease
VL  - 9
IS  - 1
SN  - 2274-5807
CY  - Cham
PB  - Springer International Publishing
M1  - DZNE-2022-00406
SP  - 77-85
PY  - 2022
AB  - Frailty is a complex geriatric syndrome arising from a combination of genetic and environmental factors and is associated with adverse health outcomes and mortality. A recent study reported an association between variants of the 9p21-23 locus, associated with a number of age-related disorders, including Alzheimer's disease (AD), and frailty. Frailty has been associated with increased risk of developing AD and it has been proposed that frailty burden may modify AD clinical presentation. In view of the overlapping genetic architecture between the two disorders, it is noteworthy to conduct studies to uncover risk variants that contribute to both AD and frailty. The purpose of this study is to test the reproducibility of the association of 9p21-23 locus with frailty in a population that is ethnically different from previous work and in the context of multidimensional definitions of frailty that will allow us to examine the potential impact to domains pertaining to AD pathology.We operationalized frailty according two definitions and the corresponding instruments, the Frailty Index (FI) and the Tilburg Frailty Indicator (TFI) and we determined genotypes of eight alleles previously identified as risk increasing for frailty in 1172 community-dwelling older participants (57
KW  - 9p21-23 locus (Other)
KW  - Alzheimer (Other)
KW  - Frailty (Other)
KW  - genetics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35098976
DO  - DOI:10.14283/jpad.2022.2
UR  - https://pub.dzne.de/record/163660
ER  -