% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mourtzi:163660,
      author       = {Mourtzi, N. and Hatzimanolis, A. and Xiromerisiou, G. and
                      Ntanasi, E. and Georgakis, M. K. and Ramirez, A. and
                      Heilmann-Heimbach, S. and Grenier-Boley, B. and Lambert, J.
                      C. and Yannakoulia, M. and Kosmidis, M. and Dardiotis, E.
                      and Hadjigeorgiou, G. and Sakka, P. and Scarmeas, N.},
      title        = {{A}ssociation between 9p21-23 {L}ocus and {F}railty in a
                      {C}ommunity-{D}welling {G}reek {P}opulation: {R}esults from
                      the {H}ellenic {L}ongitudinal {I}nvestigation of {A}geing
                      and {D}iet.},
      journal      = {The journal of prevention of Alzheimer's disease},
      volume       = {9},
      number       = {1},
      issn         = {2274-5807},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {DZNE-2022-00406},
      pages        = {77-85},
      year         = {2022},
      abstract     = {Frailty is a complex geriatric syndrome arising from a
                      combination of genetic and environmental factors and is
                      associated with adverse health outcomes and mortality. A
                      recent study reported an association between variants of the
                      9p21-23 locus, associated with a number of age-related
                      disorders, including Alzheimer's disease (AD), and frailty.
                      Frailty has been associated with increased risk of
                      developing AD and it has been proposed that frailty burden
                      may modify AD clinical presentation. In view of the
                      overlapping genetic architecture between the two disorders,
                      it is noteworthy to conduct studies to uncover risk variants
                      that contribute to both AD and frailty. The purpose of this
                      study is to test the reproducibility of the association of
                      9p21-23 locus with frailty in a population that is
                      ethnically different from previous work and in the context
                      of multidimensional definitions of frailty that will allow
                      us to examine the potential impact to domains pertaining to
                      AD pathology.We operationalized frailty according two
                      definitions and the corresponding instruments, the Frailty
                      Index (FI) and the Tilburg Frailty Indicator (TFI) and we
                      determined genotypes of eight alleles previously identified
                      as risk increasing for frailty in 1172 community-dwelling
                      older participants $(57\%$ females) from the HELIAD study
                      with a mean age of 74 years old. We cross-sectionally
                      investigated the association between risk alleles and
                      frailty, as well as with specific components of each
                      definition using linear regression analyses adjusted for
                      age, sex and years of education.Compared to non-carriers,
                      carriers of rs7038172 C risk allele, were associated with a
                      higher FI Score (β=0.089, p=0.002). Similarly, we found a
                      positive association between the presence of at least one
                      rs7038172 C variant and TFI score (β=0.053, p=0.04).
                      Moreover, the rs7038172 variant was associated,
                      irrespectively of dementia status, with the memory and
                      psychological domain of FI and TFI, respectively.Our study
                      confirms the association of the rs7038172 C allele with the
                      frailty syndrome in a Greek population and in the context of
                      multidimensional definitions of frailty. Furthermore, we
                      report novel associations between this allele and the memory
                      domain of FI and the psychological domain of TFI, that
                      includes memory problems on its components. Given that
                      frailty burden has been shown to modify the AD clinical
                      presentation, it is likely that rs7038172 C allele may
                      accelerate the transition of AD or frailty to dementia
                      Overall, our study corroborates the role of the 9p21-23
                      region in frailty development and draw potential links with
                      AD pathology.},
      keywords     = {9p21-23 locus (Other) / Alzheimer (Other) / Frailty (Other)
                      / genetics (Other)},
      cin          = {Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35098976},
      doi          = {10.14283/jpad.2022.2},
      url          = {https://pub.dzne.de/record/163660},
}