TY  - JOUR
AU  - Zülke, Andrea E
AU  - Luppa, Melanie
AU  - Röhr, Susanne
AU  - Weißenborn, Marina
AU  - Bauer, Alexander
AU  - Samos, Franziska-Antonia Zora
AU  - Kühne, Flora
AU  - Zöllinger, Isabel
AU  - Döhring, Juliane
AU  - Brettschneider, Christian
AU  - Oey, Anke
AU  - Czock, David
AU  - Frese, Thomas
AU  - Gensichen, Jochen
AU  - Haefeli, Walter E
AU  - Hoffmann, Wolfgang
AU  - Kaduszkiewicz, Hanna
AU  - König, Hans-Helmut
AU  - Thyrian, Jochen René
AU  - Wiese, Birgitt
AU  - Riedel-Heller, Steffi G
TI  - Association of mental demands in the workplace with cognitive function in older adults at increased risk for dementia.
JO  - BMC geriatrics
VL  - 21
IS  - 1
SN  - 1471-2318
CY  - London
PB  - BioMed Central
M1  - DZNE-2022-00409
SP  - 688
PY  - 2021
AB  - Growing evidence suggests a protective effect of high mental demands at work on cognitive function in later life. However, evidence on corresponding associations in older adults at increased risk for dementia is currently lacking. This study investigates the association between mental demands at work and cognitive functioning in the population of the AgeWell.de-trial.Cross-sectional investigation of the association between global cognitive functioning (Montreal Cognitive Assessment) and mental demands at work in older individuals at increased risk for dementia (Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE)score ≥ 9; n = 941, age: 60-77 years). Occupational information was matched to Occupational Information Network (O*NET)-descriptors. Associations between cognitive function and O*NET-indices executive, verbal and novelty were investigated using generalized linear models.Higher values of index verbal (b = .69, p = .002) were associated with better cognitive function when adjusting for covariates. No association was observed for indices executive (b = .37, p = .062) and novelty (b = .45, p = .119). Higher education, younger age, and employment were linked to better cognitive function, while preexisting medical conditions did not change the associations. Higher levels of depressive symptomatology were associated with worse cognitive function.Higher levels of verbal demands at work were associated with better cognitive function for older adults with increased dementia risk. This suggests an advantage for older persons in jobs with high mental demands even after retirement and despite prevalent risk factors. Longitudinal studies are warranted to confirm these results and evaluate the potential of workplaces to prevent cognitive decline through increased mental demands.
KW  - Aged
KW  - Aged, 80 and over
KW  - Cognition
KW  - Cognitive Dysfunction: diagnosis
KW  - Cognitive Dysfunction: epidemiology
KW  - Cross-Sectional Studies
KW  - Dementia: diagnosis
KW  - Dementia: epidemiology
KW  - Humans
KW  - Workplace
KW  - Cognition (Other)
KW  - Cognitive decline (Other)
KW  - Dementia (Other)
KW  - Mental demands (Other)
KW  - Occupation (Other)
KW  - Risk factors (Other)
KW  - Workplace (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34893023
C2  - pmc:PMC8665567
DO  - DOI:10.1186/s12877-021-02653-5
UR  - https://pub.dzne.de/record/163663
ER  -