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@ARTICLE{Zlke:163663,
      author       = {Zülke, Andrea E and Luppa, Melanie and Röhr, Susanne and
                      Weißenborn, Marina and Bauer, Alexander and Samos,
                      Franziska-Antonia Zora and Kühne, Flora and Zöllinger,
                      Isabel and Döhring, Juliane and Brettschneider, Christian
                      and Oey, Anke and Czock, David and Frese, Thomas and
                      Gensichen, Jochen and Haefeli, Walter E and Hoffmann,
                      Wolfgang and Kaduszkiewicz, Hanna and König, Hans-Helmut
                      and Thyrian, Jochen René and Wiese, Birgitt and
                      Riedel-Heller, Steffi G},
      title        = {{A}ssociation of mental demands in the workplace with
                      cognitive function in older adults at increased risk for
                      dementia.},
      journal      = {BMC geriatrics},
      volume       = {21},
      number       = {1},
      issn         = {1471-2318},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2022-00409},
      pages        = {688},
      year         = {2021},
      abstract     = {Growing evidence suggests a protective effect of high
                      mental demands at work on cognitive function in later life.
                      However, evidence on corresponding associations in older
                      adults at increased risk for dementia is currently lacking.
                      This study investigates the association between mental
                      demands at work and cognitive functioning in the population
                      of the AgeWell.de-trial.Cross-sectional investigation of the
                      association between global cognitive functioning (Montreal
                      Cognitive Assessment) and mental demands at work in older
                      individuals at increased risk for dementia (Cardiovascular
                      Risk Factors, Aging, and Incidence of Dementia (CAIDE)score
                      ≥ 9; n = 941, age: 60-77 years). Occupational information
                      was matched to Occupational Information Network
                      (O*NET)-descriptors. Associations between cognitive function
                      and O*NET-indices executive, verbal and novelty were
                      investigated using generalized linear models.Higher values
                      of index verbal (b = .69, p = .002) were associated with
                      better cognitive function when adjusting for covariates. No
                      association was observed for indices executive (b = .37, p =
                      .062) and novelty (b = .45, p = .119). Higher education,
                      younger age, and employment were linked to better cognitive
                      function, while preexisting medical conditions did not
                      change the associations. Higher levels of depressive
                      symptomatology were associated with worse cognitive
                      function.Higher levels of verbal demands at work were
                      associated with better cognitive function for older adults
                      with increased dementia risk. This suggests an advantage for
                      older persons in jobs with high mental demands even after
                      retirement and despite prevalent risk factors. Longitudinal
                      studies are warranted to confirm these results and evaluate
                      the potential of workplaces to prevent cognitive decline
                      through increased mental demands.},
      keywords     = {Aged / Aged, 80 and over / Cognition / Cognitive
                      Dysfunction: diagnosis / Cognitive Dysfunction: epidemiology
                      / Cross-Sectional Studies / Dementia: diagnosis / Dementia:
                      epidemiology / Humans / Workplace / Cognition (Other) /
                      Cognitive decline (Other) / Dementia (Other) / Mental
                      demands (Other) / Occupation (Other) / Risk factors (Other)
                      / Workplace (Other)},
      cin          = {AG Hoffmann / AG Thyrian},
      ddc          = {610},
      cid          = {I:(DE-2719)1510600 / I:(DE-2719)1510800},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34893023},
      pmc          = {pmc:PMC8665567},
      doi          = {10.1186/s12877-021-02653-5},
      url          = {https://pub.dzne.de/record/163663},
}