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@ARTICLE{Schwarz:163691,
      author       = {Schwarz, Claudia and Benson, Gloria S. and Antonenko, Daria
                      and Horn, Nora and Koebe, Theresa and Klimecki, Olga and
                      Sommer, Werner and Wirth, Miranka and Flöel, Agnes},
      title        = {{N}egative affective burden is associated with higher
                      resting-state functional connectivity in subjective
                      cognitive decline},
      journal      = {Scientific reports},
      volume       = {12},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2022-00435},
      pages        = {6212},
      year         = {2022},
      abstract     = {Subjective cognitive decline (SCD), as expressed by older
                      adults, is associated with negative affect, which, in turn,
                      is a likely risk factor for Alzheimer's Disease (AD). This
                      study assessed the associations between negative affective
                      burden, cognitive functioning, and functional connectivity
                      in networks vulnerable to AD in the context of SCD. Older
                      participants (60-90 years) with SCD (n = 51) and healthy
                      controls (n = 50) were investigated in a cross-sectional
                      study. Subclinical negative affective burden, quantified
                      through a composite of self-reported negative affective
                      factors, was related to cognitive functioning
                      (self-perceived and objective) and functional connectivity.
                      Seed-to-voxel analyses were carried out in default mode
                      network (DMN) and salience network (SAL) nodes using
                      resting-state functional magnetic resonance imaging. Greater
                      negative affective burden was associated with lower
                      self-perceived cognitive functioning and lower
                      between-network functional connectivity of DMN and SAL nodes
                      in the total sample. In addition, there was a significant
                      moderation of SCD status. Greater negative affective burden
                      related to higher functional connectivity within DMN
                      (posterior cingulate-to-precuneus) and within SAL (anterior
                      cingulate-to-insula) nodes in the SCD group, whereas in
                      controls the inverse association was found. We show that
                      negative affective burden is associated with functional
                      brain alterations in older adults, regardless of SCD status.
                      Specifically in the SCD phenotype, greater negative
                      affective burden relates to higher functional connectivity
                      within brain networks vulnerable to AD. Our findings imply
                      that negative affective burden should be considered a
                      potentially modifiable target for early intervention.},
      keywords     = {Aged / Alzheimer Disease / Brain: diagnostic imaging /
                      Cognitive Dysfunction: diagnostic imaging / Cross-Sectional
                      Studies / Humans / Magnetic Resonance Imaging / Neural
                      Pathways / Neuropsychological Tests},
      cin          = {AG Wirth / AG Donix / AG Teipel},
      ddc          = {600},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1710008 /
                      I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9007949},
      pubmed       = {pmid:35418579},
      doi          = {10.1038/s41598-022-10179-y},
      url          = {https://pub.dzne.de/record/163691},
}