%0 Journal Article
%A Franzmeier, Nicolai
%A Brendel, Matthias
%A Beyer, Leonie
%A Slemann, Luna
%A Kovacs, Gabor G
%A Arzberger, Thomas
%A Kurz, Carolin
%A Respondek, Gesine
%A Jecmenica Lukic, Milica
%A Biel, Davina
%A Rubinski, Anna
%A Frontzkowski, Lukas
%A Hummel, Selina
%A Müller, Andre
%A Finze, Anika
%A Palleis, Carla
%A Joseph, Emanuel
%A Weidinger, Endy
%A Katzdobler, Sabrina
%A Song, Mengmeng
%A Biechele, Gloria
%A Kern, Maike
%A Scheifele, Heinrich Maximilian
%A Rauchmann, Boris Stephan
%A Perneczky, Robert
%A Rullman, Michael
%A Patt, Marianne
%A Schildan, Andreas
%A Barthel, Henryk
%A Sabri, Osama
%A Rumpf, Jost J
%A Schroeter, Matthias L
%A Classen, Joseph
%A Villemagne, Victor
%A Seibyl, John
%A Stephens, Andrew W
%A Lee, Edward B
%A Coughlin, David G
%A Giese, Armin
%A Grossman, Murray
%A McMillan, Corey T
%A Gelpi, Ellen
%A Molina-Porcel, Laura
%A Compta, Yaroslau
%A van Swieten, John C
%A Laat, Laura Donker
%A Troakes, Claire
%A Al-Sarraj, Safa
%A Robinson, John L
%A Xie, Sharon X
%A Irwin, David J
%A Roeber, Sigrun
%A Herms, Jochen
%A Simons, Mikael
%A Bartenstein, Peter
%A Lee, Virginia M
%A Trojanowski, John Q
%A Levin, Johannes
%A Höglinger, Günter
%A Ewers, Michael
%T Tau deposition patterns are associated with functional connectivity in primary tauopathies.
%J Nature Communications
%V 13
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DZNE-2022-00446
%P 1362
%D 2022
%X Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
%K Brain: metabolism
%K Humans
%K Magnetic Resonance Imaging
%K Supranuclear Palsy, Progressive: diagnostic imaging
%K Supranuclear Palsy, Progressive: pathology
%K Tauopathies: diagnostic imaging
%K Tauopathies: pathology
%K tau Proteins: metabolism
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35292638
%2 pmc:PMC8924216
%R 10.1038/s41467-022-28896-3
%U https://pub.dzne.de/record/163707