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000163707 037__ $$aDZNE-2022-00446
000163707 041__ $$aEnglish
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000163707 1001_ $$00000-0001-9736-2283$$aFranzmeier, Nicolai$$b0
000163707 245__ $$aTau deposition patterns are associated with functional connectivity in primary tauopathies.
000163707 260__ $$a[London]$$bNature Publishing Group UK$$c2022
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000163707 520__ $$aTau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
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000163707 650_7 $$2NLM Chemicals$$atau Proteins
000163707 650_2 $$2MeSH$$aBrain: metabolism
000163707 650_2 $$2MeSH$$aHumans
000163707 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000163707 650_2 $$2MeSH$$aSupranuclear Palsy, Progressive: diagnostic imaging
000163707 650_2 $$2MeSH$$aSupranuclear Palsy, Progressive: pathology
000163707 650_2 $$2MeSH$$aTauopathies: diagnostic imaging
000163707 650_2 $$2MeSH$$aTauopathies: pathology
000163707 650_2 $$2MeSH$$atau Proteins: metabolism
000163707 7001_ $$0P:(DE-2719)9001539$$aBrendel, Matthias$$b1$$udzne
000163707 7001_ $$00000-0002-7358-4495$$aBeyer, Leonie$$b2
000163707 7001_ $$aSlemann, Luna$$b3
000163707 7001_ $$00000-0003-3841-5511$$aKovacs, Gabor G$$b4
000163707 7001_ $$0P:(DE-2719)2811333$$aArzberger, Thomas$$b5$$udzne
000163707 7001_ $$0P:(DE-2719)9000176$$aKurz, Carolin$$b6$$udzne
000163707 7001_ $$0P:(DE-2719)2811600$$aRespondek, Gesine$$b7$$udzne
000163707 7001_ $$0P:(DE-2719)2812616$$aJecmenica Lukic, Milica$$b8$$udzne
000163707 7001_ $$aBiel, Davina$$b9
000163707 7001_ $$0P:(DE-2719)2812415$$aRubinski, Anna$$b10$$udzne
000163707 7001_ $$aFrontzkowski, Lukas$$b11
000163707 7001_ $$aHummel, Selina$$b12
000163707 7001_ $$aMüller, Andre$$b13
000163707 7001_ $$00000-0002-3966-5814$$aFinze, Anika$$b14
000163707 7001_ $$0P:(DE-2719)9000852$$aPalleis, Carla$$b15$$udzne
000163707 7001_ $$aJoseph, Emanuel$$b16
000163707 7001_ $$0P:(DE-2719)9000882$$aWeidinger, Endy$$b17$$udzne
000163707 7001_ $$0P:(DE-2719)9001160$$aKatzdobler, Sabrina$$b18$$udzne
000163707 7001_ $$aSong, Mengmeng$$b19
000163707 7001_ $$aBiechele, Gloria$$b20
000163707 7001_ $$aKern, Maike$$b21
000163707 7001_ $$0P:(DE-2719)9001444$$aScheifele, Heinrich Maximilian$$b22$$udzne
000163707 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b23$$udzne
000163707 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b24$$udzne
000163707 7001_ $$aRullman, Michael$$b25
000163707 7001_ $$aPatt, Marianne$$b26
000163707 7001_ $$00000-0002-9418-3826$$aSchildan, Andreas$$b27
000163707 7001_ $$aBarthel, Henryk$$b28
000163707 7001_ $$0P:(DE-2719)2814810$$aSabri, Osama$$b29$$udzne
000163707 7001_ $$aRumpf, Jost J$$b30
000163707 7001_ $$aSchroeter, Matthias L$$b31
000163707 7001_ $$aClassen, Joseph$$b32
000163707 7001_ $$aVillemagne, Victor$$b33
000163707 7001_ $$aSeibyl, John$$b34
000163707 7001_ $$00000-0001-5052-6586$$aStephens, Andrew W$$b35
000163707 7001_ $$aLee, Edward B$$b36
000163707 7001_ $$00000-0003-4111-0102$$aCoughlin, David G$$b37
000163707 7001_ $$0P:(DE-2719)9000906$$aGiese, Armin$$b38$$udzne
000163707 7001_ $$aGrossman, Murray$$b39
000163707 7001_ $$aMcMillan, Corey T$$b40
000163707 7001_ $$aGelpi, Ellen$$b41
000163707 7001_ $$00000-0003-4068-8578$$aMolina-Porcel, Laura$$b42
000163707 7001_ $$aCompta, Yaroslau$$b43
000163707 7001_ $$avan Swieten, John C$$b44
000163707 7001_ $$aLaat, Laura Donker$$b45
000163707 7001_ $$00000-0002-1790-7376$$aTroakes, Claire$$b46
000163707 7001_ $$aAl-Sarraj, Safa$$b47
000163707 7001_ $$aRobinson, John L$$b48
000163707 7001_ $$aXie, Sharon X$$b49
000163707 7001_ $$00000-0002-5599-5098$$aIrwin, David J$$b50
000163707 7001_ $$aRoeber, Sigrun$$b51
000163707 7001_ $$0P:(DE-2719)2810441$$aHerms, Jochen$$b52$$udzne
000163707 7001_ $$0P:(DE-2719)2811642$$aSimons, Mikael$$b53$$udzne
000163707 7001_ $$aBartenstein, Peter$$b54
000163707 7001_ $$aLee, Virginia M$$b55
000163707 7001_ $$0P:(DE-2719)9000946$$aTrojanowski, John Q$$b56$$udzne
000163707 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b57$$udzne
000163707 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter$$b58$$udzne
000163707 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b59$$eLast author$$udzne
000163707 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-022-28896-3$$gVol. 13, no. 1, p. 1362$$n1$$p1362$$tNature Communications$$v13$$x2041-1723$$y2022
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