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@ARTICLE{Franzmeier:163707,
      author       = {Franzmeier, Nicolai and Brendel, Matthias and Beyer, Leonie
                      and Slemann, Luna and Kovacs, Gabor G and Arzberger, Thomas
                      and Kurz, Carolin and Respondek, Gesine and Jecmenica Lukic,
                      Milica and Biel, Davina and Rubinski, Anna and Frontzkowski,
                      Lukas and Hummel, Selina and Müller, Andre and Finze, Anika
                      and Palleis, Carla and Joseph, Emanuel and Weidinger, Endy
                      and Katzdobler, Sabrina and Song, Mengmeng and Biechele,
                      Gloria and Kern, Maike and Scheifele, Heinrich Maximilian
                      and Rauchmann, Boris Stephan and Perneczky, Robert and
                      Rullman, Michael and Patt, Marianne and Schildan, Andreas
                      and Barthel, Henryk and Sabri, Osama and Rumpf, Jost J and
                      Schroeter, Matthias L and Classen, Joseph and Villemagne,
                      Victor and Seibyl, John and Stephens, Andrew W and Lee,
                      Edward B and Coughlin, David G and Giese, Armin and
                      Grossman, Murray and McMillan, Corey T and Gelpi, Ellen and
                      Molina-Porcel, Laura and Compta, Yaroslau and van Swieten,
                      John C and Laat, Laura Donker and Troakes, Claire and
                      Al-Sarraj, Safa and Robinson, John L and Xie, Sharon X and
                      Irwin, David J and Roeber, Sigrun and Herms, Jochen and
                      Simons, Mikael and Bartenstein, Peter and Lee, Virginia M
                      and Trojanowski, John Q and Levin, Johannes and Höglinger,
                      Günter and Ewers, Michael},
      title        = {{T}au deposition patterns are associated with functional
                      connectivity in primary tauopathies.},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2022-00446},
      pages        = {1362},
      year         = {2022},
      abstract     = {Tau pathology is the main driver of neuronal dysfunction in
                      4-repeat tauopathies, including cortico-basal degeneration
                      and progressive supranuclear palsy. Tau is assumed to spread
                      prion-like across connected neurons, but the mechanisms of
                      tau propagation are largely elusive in 4-repeat tauopathies,
                      characterized not only by neuronal but also by astroglial
                      and oligodendroglial tau accumulation. Here, we assess
                      whether connectivity is associated with 4R-tau deposition
                      patterns by combining resting-state fMRI connectomics with
                      both 2nd generation 18F-PI-2620 tau-PET in 46 patients with
                      clinically diagnosed 4-repeat tauopathies and post-mortem
                      cell-type-specific regional tau assessments from two
                      independent progressive supranuclear palsy patient samples
                      (n = 97 and n = 96). We find that inter-regional
                      connectivity is associated with higher inter-regional
                      correlation of both tau-PET and post-mortem tau levels in
                      4-repeat tauopathies. In regional cell-type specific
                      post-mortem tau assessments, this association is stronger
                      for neuronal than for astroglial or oligodendroglial tau,
                      suggesting that connectivity is primarily associated with
                      neuronal tau accumulation. Using tau-PET we find further
                      that patient-level tau patterns are associated with the
                      connectivity of subcortical tau epicenters. Together, the
                      current study provides combined in vivo tau-PET and
                      histopathological evidence that brain connectivity is
                      associated with tau deposition patterns in 4-repeat
                      tauopathies.},
      keywords     = {Brain: metabolism / Humans / Magnetic Resonance Imaging /
                      Supranuclear Palsy, Progressive: diagnostic imaging /
                      Supranuclear Palsy, Progressive: pathology / Tauopathies:
                      diagnostic imaging / Tauopathies: pathology / tau Proteins:
                      metabolism / tau Proteins (NLM Chemicals)},
      cin          = {AG Simons / Neuropathology / Brainbank / AG Höglinger 1 /
                      AG Höglinger 2 / Clinical Dementia Research München / AG
                      Herms},
      ddc          = {500},
      cid          = {I:(DE-2719)1110008 / I:(DE-2719)1140013 /
                      I:(DE-2719)1110002 / I:(DE-2719)1111015 / I:(DE-2719)1111016
                      / I:(DE-2719)1110001},
      pnm          = {351 - Brain Function (POF4-351) / 353 - Clinical and Health
                      Care Research (POF4-353) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-353 /
                      G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35292638},
      pmc          = {pmc:PMC8924216},
      doi          = {10.1038/s41467-022-28896-3},
      url          = {https://pub.dzne.de/record/163707},
}