Home > Publications Database > Tau deposition patterns are associated with functional connectivity in primary tauopathies. > print

001     163707
005     20230915090531.0
024 7 _ |a 10.1038/s41467-022-28896-3
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024 7 _ |a pmc:PMC8924216
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037 _ _ |a DZNE-2022-00446
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Franzmeier, Nicolai
|0 0000-0001-9736-2283
|b 0
245 _ _ |a Tau deposition patterns are associated with functional connectivity in primary tauopathies.
260 _ _ |a [London]
|c 2022
|b Nature Publishing Group UK
336 7 _ |a article
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520 _ _ |a Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: diagnostic imaging
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: pathology
|2 MeSH
650 _ 2 |a Tauopathies: diagnostic imaging
|2 MeSH
650 _ 2 |a Tauopathies: pathology
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
|2 MeSH
700 1 _ |a Brendel, Matthias
|0 P:(DE-2719)9001539
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700 1 _ |a Beyer, Leonie
|0 0000-0002-7358-4495
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700 1 _ |a Slemann, Luna
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700 1 _ |a Kovacs, Gabor G
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700 1 _ |a Arzberger, Thomas
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700 1 _ |a Kurz, Carolin
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700 1 _ |a Respondek, Gesine
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700 1 _ |a Jecmenica Lukic, Milica
|0 P:(DE-2719)2812616
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700 1 _ |a Biel, Davina
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700 1 _ |a Rubinski, Anna
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700 1 _ |a Frontzkowski, Lukas
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700 1 _ |a Hummel, Selina
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700 1 _ |a Müller, Andre
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700 1 _ |a Finze, Anika
|0 0000-0002-3966-5814
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700 1 _ |a Palleis, Carla
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700 1 _ |a Joseph, Emanuel
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700 1 _ |a Weidinger, Endy
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700 1 _ |a Katzdobler, Sabrina
|0 P:(DE-2719)9001160
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700 1 _ |a Song, Mengmeng
|b 19
700 1 _ |a Biechele, Gloria
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700 1 _ |a Kern, Maike
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700 1 _ |a Scheifele, Heinrich Maximilian
|0 P:(DE-2719)9001444
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700 1 _ |a Rauchmann, Boris Stephan
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700 1 _ |a Perneczky, Robert
|0 P:(DE-2719)2812234
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700 1 _ |a Rullman, Michael
|b 25
700 1 _ |a Patt, Marianne
|b 26
700 1 _ |a Schildan, Andreas
|0 0000-0002-9418-3826
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700 1 _ |a Barthel, Henryk
|b 28
700 1 _ |a Sabri, Osama
|0 P:(DE-2719)2814810
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700 1 _ |a Rumpf, Jost J
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700 1 _ |a Schroeter, Matthias L
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700 1 _ |a Classen, Joseph
|b 32
700 1 _ |a Villemagne, Victor
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700 1 _ |a Seibyl, John
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700 1 _ |a Stephens, Andrew W
|0 0000-0001-5052-6586
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700 1 _ |a Lee, Edward B
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700 1 _ |a Coughlin, David G
|0 0000-0003-4111-0102
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700 1 _ |a Giese, Armin
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700 1 _ |a Grossman, Murray
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700 1 _ |a McMillan, Corey T
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700 1 _ |a Gelpi, Ellen
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700 1 _ |a Molina-Porcel, Laura
|0 0000-0003-4068-8578
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700 1 _ |a Compta, Yaroslau
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700 1 _ |a van Swieten, John C
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700 1 _ |a Laat, Laura Donker
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700 1 _ |a Troakes, Claire
|0 0000-0002-1790-7376
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700 1 _ |a Al-Sarraj, Safa
|b 47
700 1 _ |a Robinson, John L
|b 48
700 1 _ |a Xie, Sharon X
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700 1 _ |a Irwin, David J
|0 0000-0002-5599-5098
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700 1 _ |a Roeber, Sigrun
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700 1 _ |a Herms, Jochen
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700 1 _ |a Simons, Mikael
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700 1 _ |a Bartenstein, Peter
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700 1 _ |a Lee, Virginia M
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700 1 _ |a Trojanowski, John Q
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700 1 _ |a Levin, Johannes
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700 1 _ |a Höglinger, Günter
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700 1 _ |a Ewers, Michael
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|e Last author
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773 _ _ |a 10.1038/s41467-022-28896-3
|g Vol. 13, no. 1, p. 1362
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|y 2022
|x 2041-1723
856 4 _ |y OpenAccess
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