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000163715 0247_ $$2doi$$a10.1016/j.cortex.2022.01.012
000163715 0247_ $$2pmid$$apmid:35325762
000163715 0247_ $$2ISSN$$a0010-9452
000163715 0247_ $$2ISSN$$a1973-8102
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000163715 037__ $$aDZNE-2022-00454
000163715 041__ $$aEnglish
000163715 082__ $$a610
000163715 1001_ $$aFoster, Phoebe H$$b0
000163715 245__ $$aExamining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort.
000163715 260__ $$aNew York, NY$$bElsevier$$c2022
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000163715 520__ $$aReduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD.Empathy was examined using a modified version of the Interpersonal Reactivity Index (mIRI) in 676 participants from the Genetic FTD Initiative: 216 mutation-negative controls, 192 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. Using global scores from the CDR® plus NACC FTLD, mutation carriers were divided into three groups, asymptomatic (0), very mildly symptomatic/prodromal (.5), or fully symptomatic (1 or more). The mIRI Total score, as well as the subscores of Empathic Concern (EC) and Perspective Taking (PT) were assessed. Linear regression models with bootstrapping were used to assess empathy ratings across genetic groups, as well as across phenotypes in the symptomatic carriers. Neural correlates of empathy deficits were examined using a voxel-based morphometry (VBM) analysis.All fully symptomatic groups scored lower on the mIRI Total, EC, and PT when compared to controls and their asymptomatic or prodromal counterparts (all p < .001). Prodromal C9orf72 expansion carriers also scored significantly lower than controls on the mIRI Total score (p = .046). In the phenotype analysis, all groups (behavioural variant FTD, primary progressive aphasia and FTD with amyotrophic lateral sclerosis) scored significantly lower than controls (all p < .007). VBM revealed an overlapping neural correlate of the mIRI Total score across genetic groups in the orbitofrontal lobe but with additional involvement in the temporal lobe, insula and basal ganglia in both the GRN and MAPT groups, and uniquely more posterior regions such as the parietal lobe and thalamus in the GRN group, and medial temporal structures in the MAPT group.Significant empathy deficits present in genetic FTD, particularly in symptomatic individuals and those with a bvFTD phenotype, while prodromal deficits are only seen using the mIRI in C9orf72 expansion carriers.
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000163715 650_7 $$2Other$$aEmpathic concern
000163715 650_7 $$2Other$$aEmpathy
000163715 650_7 $$2Other$$aFrontotemporal dementia
000163715 650_7 $$2Other$$aInterpersonal Reactivity Index
000163715 650_7 $$2Other$$aPerspective taking
000163715 650_2 $$2MeSH$$aC9orf72 Protein: genetics
000163715 650_2 $$2MeSH$$aEmpathy
000163715 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnosis
000163715 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000163715 650_2 $$2MeSH$$aHumans
000163715 650_2 $$2MeSH$$aMutation
000163715 650_2 $$2MeSH$$aPick Disease of the Brain
000163715 650_2 $$2MeSH$$aProgranulins: genetics
000163715 650_2 $$2MeSH$$atau Proteins: genetics
000163715 7001_ $$aRussell, Lucy L$$b1
000163715 7001_ $$aPeakman, Georgia$$b2
000163715 7001_ $$aConvery, Rhian S$$b3
000163715 7001_ $$aBouzigues, Arabella$$b4
000163715 7001_ $$aGreaves, Caroline V$$b5
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000163715 7001_ $$avan Swieten, John C$$b8
000163715 7001_ $$aJiskoot, Lize C$$b9
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000163715 7001_ $$aSanchez-Valle, Raquel$$b11
000163715 7001_ $$aLaforce, Robert$$b12
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000163715 7001_ $$aMasellis, Mario$$b14
000163715 7001_ $$aTartaglia, Carmela$$b15
000163715 7001_ $$aRowe, James B$$b16
000163715 7001_ $$aBorroni, Barbara$$b17
000163715 7001_ $$aFinger, Elizabeth$$b18
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000163715 7001_ $$aGalimberti, Daniela$$b20
000163715 7001_ $$aVandenberghe, Rik$$b21
000163715 7001_ $$ade Mendonça, Alexandre$$b22
000163715 7001_ $$aButler, Chris R$$b23
000163715 7001_ $$aGerhard, Alex$$b24
000163715 7001_ $$aDucharme, Simon$$b25
000163715 7001_ $$aLe Ber, Isabelle$$b26
000163715 7001_ $$aTagliavini, Fabrizio$$b27
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000163715 7001_ $$aPasquier, Florence$$b29
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000163715 7001_ $$aRohrer, Jonathan D$$b34
000163715 7001_ $$aInitiative, Genetic FTD$$b35$$eCollaboration Author
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