TY  - JOUR
AU  - Foster, Phoebe H
AU  - Russell, Lucy L
AU  - Peakman, Georgia
AU  - Convery, Rhian S
AU  - Bouzigues, Arabella
AU  - Greaves, Caroline V
AU  - Bocchetta, Martina
AU  - Cash, David M
AU  - van Swieten, John C
AU  - Jiskoot, Lize C
AU  - Moreno, Fermin
AU  - Sanchez-Valle, Raquel
AU  - Laforce, Robert
AU  - Graff, Caroline
AU  - Masellis, Mario
AU  - Tartaglia, Carmela
AU  - Rowe, James B
AU  - Borroni, Barbara
AU  - Finger, Elizabeth
AU  - Synofzik, Matthis
AU  - Galimberti, Daniela
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Butler, Chris R
AU  - Gerhard, Alex
AU  - Ducharme, Simon
AU  - Le Ber, Isabelle
AU  - Tagliavini, Fabrizio
AU  - Santana, Isabel
AU  - Pasquier, Florence
AU  - Levin, Johannes
AU  - Danek, Adrian
AU  - Otto, Markus
AU  - Sorbi, Sandro
AU  - Rohrer, Jonathan D
AU  - Afonso, Sónia
AU  - Almeida, Maria Rosario
AU  - Anderl-Straub, Sarah
AU  - Andersson, Christin
AU  - Antonell, Anna
AU  - Archetti, Silvana
AU  - Arighi, Andrea
AU  - Balasa, Mircea
AU  - Barandiaran, Myriam
AU  - Bargalló, Nuria
AU  - Bartha, Robart
AU  - Bender, Benjamin
AU  - Benussi, Alberto
AU  - Bertoux, Maxime
AU  - Bertrand, Anne
AU  - Bessi, Valentina
AU  - Black, Sandra
AU  - Borrego-Ecija, Sergi
AU  - Bras, Jose
AU  - Brice, Alexis
AU  - Bruffaerts, Rose
AU  - Camuzat, Agnès
AU  - Cañada, Marta
AU  - Cantoni, Valentina
AU  - Caroppo, Paola
AU  - Cash, David
AU  - Castelo-Branco, Miguel
AU  - Colliot, Olivier
AU  - Cope, Thomas
AU  - Deramecourt, Vincent
AU  - de Arriba, María
AU  - Di Fede, Giuseppe
AU  - Díez, Alina
AU  - Duro, Diana
AU  - Fenoglio, Chiara
AU  - Ferrari, Camilla
AU  - Ferreira, Catarina B
AU  - Fox, Nick
AU  - Freedman, Morris
AU  - Fumagalli, Giorgio
AU  - Funkiewiez, Aurélie
AU  - Gabilondo, Alazne
AU  - Gasparotti, Roberto
AU  - Gauthier, Serge
AU  - Gazzina, Stefano
AU  - Giaccone, Giorgio
AU  - Gorostidi, Ana
AU  - Greaves, Caroline
AU  - Guerreiro, Rita
AU  - Heller, Carolin
AU  - Hoegen, Tobias
AU  - Indakoetxea, Begoña
AU  - Jelic, Vesna
AU  - Karnath, Hans Otto
AU  - Keren, Ron
AU  - Kuchcinski, Gregory
AU  - Langheinrich, Tobias
AU  - Lebouvier, Thibaud
AU  - Leitão, Maria João
AU  - Lladó, Albert
AU  - Lombardi, Gemma
AU  - Loosli, Sandra
AU  - Maruta, Carolina
AU  - Mead, Simon
AU  - Meeter, Lieke
AU  - Miltenberger, Gabriel
AU  - van Minkelen, Rick
AU  - Mitchell, Sara
AU  - Moore, Katrina
AU  - Nacmias, Benedetta
AU  - Nelson, Annabel
AU  - Öijerstedt, Linn
AU  - Olives, Jaume
AU  - Ourselin, Sebastien
AU  - Padovani, Alessandro
AU  - Panman, Jessica
AU  - Papma, Janne M
AU  - Pijnenburg, Yolande
AU  - Polito, Cristina
AU  - Premi, Enrico
AU  - Prioni, Sara
AU  - Prix, Catharina
AU  - Rademakers, Rosa
AU  - Redaelli, Veronica
AU  - Rinaldi, Daisy
AU  - Rittman, Tim
AU  - Rogaeva, Ekaterina
AU  - Rollin, Adeline
AU  - Rosa-Neto, Pedro
AU  - Rossi, Giacomina
AU  - Rossor, Martin
AU  - Santiago, Beatriz
AU  - Saracino, Dario
AU  - Sayah, Sabrina
AU  - Scarpini, Elio
AU  - Schönecker, Sonja
AU  - Seelaar, Harro
AU  - Semler, Elisa
AU  - Shafei, Rachelle
AU  - Shoesmith, Christen
AU  - Swift, Imogen
AU  - Tábuas-Pereira, Miguel
AU  - Tainta, Mikel
AU  - Taipa, Ricardo
AU  - Tang-Wai, David
AU  - Thomas, David L
AU  - Thompson, Paul
AU  - Thonberg, Hakan
AU  - Timberlake, Carolyn
AU  - Tiraboschi, Pietro
AU  - Todd, Emily
AU  - Van Damme, Philip
AU  - Vandenbulcke, Mathieu
AU  - Veldsman, Michele
AU  - Verdelho, Ana
AU  - Villanua, Jorge
AU  - Warren, Jason
AU  - Wilke, Carlo
AU  - Woollacott, Ione
AU  - Wlasich, Elisabeth
AU  - Zetterberg, Henrik
AU  - Zulaica, Miren
TI  - Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort.
JO  - Cortex
VL  - 150
SN  - 0010-9452
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2022-00454
SP  - 12 - 28
PY  - 2022
N1  - (CC BY)
AB  - Reduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD.Empathy was examined using a modified version of the Interpersonal Reactivity Index (mIRI) in 676 participants from the Genetic FTD Initiative: 216 mutation-negative controls, 192 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. Using global scores from the CDR® plus NACC FTLD, mutation carriers were divided into three groups, asymptomatic (0), very mildly symptomatic/prodromal (.5), or fully symptomatic (1 or more). The mIRI Total score, as well as the subscores of Empathic Concern (EC) and Perspective Taking (PT) were assessed. Linear regression models with bootstrapping were used to assess empathy ratings across genetic groups, as well as across phenotypes in the symptomatic carriers. Neural correlates of empathy deficits were examined using a voxel-based morphometry (VBM) analysis.All fully symptomatic groups scored lower on the mIRI Total, EC, and PT when compared to controls and their asymptomatic or prodromal counterparts (all p < .001). Prodromal C9orf72 expansion carriers also scored significantly lower than controls on the mIRI Total score (p = .046). In the phenotype analysis, all groups (behavioural variant FTD, primary progressive aphasia and FTD with amyotrophic lateral sclerosis) scored significantly lower than controls (all p < .007). VBM revealed an overlapping neural correlate of the mIRI Total score across genetic groups in the orbitofrontal lobe but with additional involvement in the temporal lobe, insula and basal ganglia in both the GRN and MAPT groups, and uniquely more posterior regions such as the parietal lobe and thalamus in the GRN group, and medial temporal structures in the MAPT group.Significant empathy deficits present in genetic FTD, particularly in symptomatic individuals and those with a bvFTD phenotype, while prodromal deficits are only seen using the mIRI in C9orf72 expansion carriers.
KW  - C9orf72 Protein: genetics
KW  - Empathy
KW  - Frontotemporal Dementia: diagnosis
KW  - Frontotemporal Dementia: genetics
KW  - Humans
KW  - Mutation
KW  - Pick Disease of the Brain
KW  - Progranulins: genetics
KW  - tau Proteins: genetics
KW  - Empathic concern (Other)
KW  - Empathy (Other)
KW  - Frontotemporal dementia (Other)
KW  - Interpersonal Reactivity Index (Other)
KW  - Perspective taking (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9067453
C6  - pmid:35325762
DO  - DOI:10.1016/j.cortex.2022.01.012
UR  - https://pub.dzne.de/record/163715
ER  -