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@ARTICLE{Foster:163715,
author = {Foster, Phoebe H and Russell, Lucy L and Peakman, Georgia
and Convery, Rhian S and Bouzigues, Arabella and Greaves,
Caroline V and Bocchetta, Martina and Cash, David M and van
Swieten, John C and Jiskoot, Lize C and Moreno, Fermin and
Sanchez-Valle, Raquel and Laforce, Robert and Graff,
Caroline and Masellis, Mario and Tartaglia, Carmela and
Rowe, James B and Borroni, Barbara and Finger, Elizabeth and
Synofzik, Matthis and Galimberti, Daniela and Vandenberghe,
Rik and de Mendonça, Alexandre and Butler, Chris R and
Gerhard, Alex and Ducharme, Simon and Le Ber, Isabelle and
Tagliavini, Fabrizio and Santana, Isabel and Pasquier,
Florence and Levin, Johannes and Danek, Adrian and Otto,
Markus and Sorbi, Sandro and Rohrer, Jonathan D and Afonso,
Sónia and Almeida, Maria Rosario and Anderl-Straub, Sarah
and Andersson, Christin and Antonell, Anna and Archetti,
Silvana and Arighi, Andrea and Balasa, Mircea and
Barandiaran, Myriam and Bargalló, Nuria and Bartha, Robart
and Bender, Benjamin and Benussi, Alberto and Bertoux,
Maxime and Bertrand, Anne and Bessi, Valentina and Black,
Sandra and Borrego-Ecija, Sergi and Bras, Jose and Brice,
Alexis and Bruffaerts, Rose and Camuzat, Agnès and Cañada,
Marta and Cantoni, Valentina and Caroppo, Paola and Cash,
David and Castelo-Branco, Miguel and Colliot, Olivier and
Cope, Thomas and Deramecourt, Vincent and de Arriba, María
and Di Fede, Giuseppe and Díez, Alina and Duro, Diana and
Fenoglio, Chiara and Ferrari, Camilla and Ferreira, Catarina
B and Fox, Nick and Freedman, Morris and Fumagalli, Giorgio
and Funkiewiez, Aurélie and Gabilondo, Alazne and
Gasparotti, Roberto and Gauthier, Serge and Gazzina, Stefano
and Giaccone, Giorgio and Gorostidi, Ana and Greaves,
Caroline and Guerreiro, Rita and Heller, Carolin and Hoegen,
Tobias and Indakoetxea, Begoña and Jelic, Vesna and
Karnath, Hans Otto and Keren, Ron and Kuchcinski, Gregory
and Langheinrich, Tobias and Lebouvier, Thibaud and Leitão,
Maria João and Lladó, Albert and Lombardi, Gemma and
Loosli, Sandra and Maruta, Carolina and Mead, Simon and
Meeter, Lieke and Miltenberger, Gabriel and van Minkelen,
Rick and Mitchell, Sara and Moore, Katrina and Nacmias,
Benedetta and Nelson, Annabel and Öijerstedt, Linn and
Olives, Jaume and Ourselin, Sebastien and Padovani,
Alessandro and Panman, Jessica and Papma, Janne M and
Pijnenburg, Yolande and Polito, Cristina and Premi, Enrico
and Prioni, Sara and Prix, Catharina and Rademakers, Rosa
and Redaelli, Veronica and Rinaldi, Daisy and Rittman, Tim
and Rogaeva, Ekaterina and Rollin, Adeline and Rosa-Neto,
Pedro and Rossi, Giacomina and Rossor, Martin and Santiago,
Beatriz and Saracino, Dario and Sayah, Sabrina and Scarpini,
Elio and Schönecker, Sonja and Seelaar, Harro and Semler,
Elisa and Shafei, Rachelle and Shoesmith, Christen and
Swift, Imogen and Tábuas-Pereira, Miguel and Tainta, Mikel
and Taipa, Ricardo and Tang-Wai, David and Thomas, David L
and Thompson, Paul and Thonberg, Hakan and Timberlake,
Carolyn and Tiraboschi, Pietro and Todd, Emily and Van
Damme, Philip and Vandenbulcke, Mathieu and Veldsman,
Michele and Verdelho, Ana and Villanua, Jorge and Warren,
Jason and Wilke, Carlo and Woollacott, Ione and Wlasich,
Elisabeth and Zetterberg, Henrik and Zulaica, Miren},
collaboration = {Initiative, Genetic FTD},
title = {{E}xamining empathy deficits across familial forms of
frontotemporal dementia within the {GENFI} cohort.},
journal = {Cortex},
volume = {150},
issn = {0010-9452},
address = {New York, NY},
publisher = {Elsevier},
reportid = {DZNE-2022-00454},
pages = {12 - 28},
year = {2022},
note = {(CC BY)},
abstract = {Reduced empathy is a common symptom in frontotemporal
dementia (FTD). Although empathy deficits have been
extensively researched in sporadic cases, few studies have
explored the differences in familial forms of FTD.Empathy
was examined using a modified version of the Interpersonal
Reactivity Index (mIRI) in 676 participants from the Genetic
FTD Initiative: 216 mutation-negative controls, 192 C9orf72
expansion carriers, 193 GRN mutation carriers and 75 MAPT
mutation carriers. Using global scores from the CDR® plus
NACC FTLD, mutation carriers were divided into three groups,
asymptomatic (0), very mildly symptomatic/prodromal (.5), or
fully symptomatic (1 or more). The mIRI Total score, as well
as the subscores of Empathic Concern (EC) and Perspective
Taking (PT) were assessed. Linear regression models with
bootstrapping were used to assess empathy ratings across
genetic groups, as well as across phenotypes in the
symptomatic carriers. Neural correlates of empathy deficits
were examined using a voxel-based morphometry (VBM)
analysis.All fully symptomatic groups scored lower on the
mIRI Total, EC, and PT when compared to controls and their
asymptomatic or prodromal counterparts (all p < .001).
Prodromal C9orf72 expansion carriers also scored
significantly lower than controls on the mIRI Total score (p
= .046). In the phenotype analysis, all groups (behavioural
variant FTD, primary progressive aphasia and FTD with
amyotrophic lateral sclerosis) scored significantly lower
than controls (all p < .007). VBM revealed an overlapping
neural correlate of the mIRI Total score across genetic
groups in the orbitofrontal lobe but with additional
involvement in the temporal lobe, insula and basal ganglia
in both the GRN and MAPT groups, and uniquely more posterior
regions such as the parietal lobe and thalamus in the GRN
group, and medial temporal structures in the MAPT
group.Significant empathy deficits present in genetic FTD,
particularly in symptomatic individuals and those with a
bvFTD phenotype, while prodromal deficits are only seen
using the mIRI in C9orf72 expansion carriers.},
keywords = {C9orf72 Protein: genetics / Empathy / Frontotemporal
Dementia: diagnosis / Frontotemporal Dementia: genetics /
Humans / Mutation / Pick Disease of the Brain /
Progranulins: genetics / tau Proteins: genetics / Empathic
concern (Other) / Empathy (Other) / Frontotemporal dementia
(Other) / Interpersonal Reactivity Index (Other) /
Perspective taking (Other)},
cin = {AG Gasser 1 / Clinical Dementia Research München},
ddc = {610},
cid = {I:(DE-2719)1210000 / I:(DE-2719)1111016},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC9067453},
pubmed = {pmid:35325762},
doi = {10.1016/j.cortex.2022.01.012},
url = {https://pub.dzne.de/record/163715},
}
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