guest ::
| Home > Publications Database > Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury. > print |
| Home > Publications Database > Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury. > print |
| 001 | 163734 | ||
| 005 | 20230915090534.0 | ||
| 024 | 7 | _ | |a 10.1523/JNEUROSCI.1305-21.2022 |2 doi |
| 024 | 7 | _ | |a pmid:35149515 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC8944241 |2 pmc |
| 024 | 7 | _ | |a 0270-6474 |2 ISSN |
| 024 | 7 | _ | |a 1529-2401 |2 ISSN |
| 024 | 7 | _ | |a altmetric:122950065 |2 altmetric |
| 037 | _ | _ | |a DZNE-2022-00473 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Meyer Zu Reckendorf, Sofia |0 0000-0001-6978-1915 |b 0 |
| 245 | _ | _ | |a Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury. |
| 260 | _ | _ | |a Washington, DC |c 2022 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1677859836_10793 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a In postmitotic neurons, several tumor suppressor genes (TSGs), including p53, Rb, and PTEN, modulate the axon regeneration success after injury. Particularly, PTEN inhibition is a key driver of successful CNS axon regeneration after optic nerve or spinal cord injury. In contrast, in peripheral neurons, TSG influence in neuronal morphology, physiology, and pathology has not been investigated to the same depth. In this study, we conditionally deleted PTEN from mouse facial motoneurons (Chat-Cre/PtenloxP/loxP ) and analyzed neuronal responses in vivo with or without peripheral facial nerve injury in male and female mice. In uninjured motoneurons, PTEN loss induced somatic, axonal, and nerve hypertrophy, synaptic terminal enlargement and reduction in physiological whisker movement. Despite these morphologic and physiological changes, PTEN deletion positively regulated facial nerve regeneration and recovery of whisker movement after nerve injury. Regenerating PTEN-deficient motoneurons upregulated P-CREB and a signaling pathway involving P-Akt, P-PRAS40, P-mTOR, and P-4EBP1. In aged mice (12 months), PTEN deletion induced hair loss and facial hyperplasia of the epidermis. This suggests a time window in younger mice with PTEN loss stimulating axon growth after injury, however, at the risk of hyperplasia formation at later time points in the old animal. Overall, our data highlight a dual TSG function with PTEN loss impairing physiological neuron function but furthermore underscoring the positive effects of PTEN ablation in axon regeneration also for the PNS.SIGNIFICANCE STATEMENT Tumor suppressor genes (TSGs) restrict cell proliferation and growth. TSG inhibition, including p53 and PTEN, stimulates axon regeneration after CNS injury. In contrast, in PNS axon regeneration, TSGs have not been analyzed in great depth. Herein we show enhanced peripheral axon regeneration after PTEN deletion from facial motoneurons. This invokes a signaling cascade with novel PTEN partners, including CREB and PRAS40. In adult mice, PTEN loss induces hyperplasia of the skin epidermis, suggesting detrimental consequences when reaching adulthood in contrast to a beneficial TSG role for regeneration in young adult mice. Thus, our data highlight the double-edged sword nature of interfering with TSG function. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 542 | _ | _ | |i 2022-09-23 |2 Crossref |u https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Akt |2 Other |
| 650 | _ | 7 | |a CREB |2 Other |
| 650 | _ | 7 | |a PTEN |2 Other |
| 650 | _ | 7 | |a facial nerve |2 Other |
| 650 | _ | 7 | |a motoneuron |2 Other |
| 650 | _ | 7 | |a nerve regeneration |2 Other |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Axons: physiology |2 MeSH |
| 650 | _ | 2 | |a Facial Nerve Injuries: genetics |2 MeSH |
| 650 | _ | 2 | |a Facial Nerve Injuries: pathology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Hyperplasia: pathology |2 MeSH |
| 650 | _ | 2 | |a Hypertrophy: pathology |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Motor Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Nerve Regeneration: genetics |2 MeSH |
| 650 | _ | 2 | |a PTEN Phosphohydrolase: metabolism |2 MeSH |
| 650 | _ | 2 | |a Tumor Suppressor Protein p53 |2 MeSH |
| 700 | 1 | _ | |a Moser, Diana |b 1 |
| 700 | 1 | _ | |a Blechschmidt, Anna |b 2 |
| 700 | 1 | _ | |a Joga, Venkata Neeha |b 3 |
| 700 | 1 | _ | |a Sinske, Daniela |b 4 |
| 700 | 1 | _ | |a Hegler, Jutta |b 5 |
| 700 | 1 | _ | |a Deininger, Stefanie |b 6 |
| 700 | 1 | _ | |a Castanese, Alberto |0 P:(DE-2719)9001873 |b 7 |u dzne |
| 700 | 1 | _ | |a Vettorazzi, Sabine |b 8 |
| 700 | 1 | _ | |a Antoniadis, Gregor |b 9 |
| 700 | 1 | _ | |a Böckers, Tobias |0 P:(DE-2719)2812855 |b 10 |u dzne |
| 700 | 1 | _ | |a Knöll, Bernd |0 0000-0001-7685-3796 |b 11 |
| 773 | 1 | 8 | |a 10.1523/jneurosci.1305-21.2022 |b Society for Neuroscience |d 2022-02-11 |n 12 |p 2474-2491 |3 journal-article |2 Crossref |t The Journal of Neuroscience |v 42 |y 2022 |x 0270-6474 |
| 773 | _ | _ | |a 10.1523/JNEUROSCI.1305-21.2022 |g Vol. 42, no. 12, p. 2474 - 2491 |0 PERI:(DE-600)1475274-8 |n 12 |p 2474-2491 |t The journal of neuroscience |v 42 |y 2022 |x 0270-6474 |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:163734 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)9001873 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 10 |6 P:(DE-2719)2812855 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-30 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-13 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J NEUROSCI : 2021 |d 2022-11-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-13 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-13 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b J NEUROSCI : 2021 |d 2022-11-13 |
| 920 | 1 | _ | |0 I:(DE-2719)1910002 |k AG Böckers |l Translational Protein Biochemistry |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1910002 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |a 10.1016/j.expneurol.2016.03.012 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1007/s00401-020-02151-9 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1084/jem.20181406 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.15252/emmm.202013131 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/ENEURO.0358-16.2016 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/ncomms4670 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/JNEUROSCI.6271-09.2010 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/s41583-020-0269-3 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/sj.emboj.7601292 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.3389/fncel.2019.00128 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.7554/eLife.29241 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.neuroscience.2007.10.048 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.expneurol.2018.02.012 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.expneurol.2018.01.005 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.neuron.2004.10.030 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1098/rsob.160091 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/nn.4425 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1371/journal.pone.0045806 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1126/science.1065518 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1158/0008-5472.CAN-10-3399 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.4103/1673-5374.189160 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.expneurol.2016.02.013 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/0169-328X(94)90098-1 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/ENEURO.0025-19.2019 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/s41419-018-1289-z |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1101/cshperspect.a020487 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/JNEUROSCI.1249-15.2015 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/JNEUROSCI.4340-10.2010 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/s42003-019-0524-1 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1371/journal.pone.0007820 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/nn.2603 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.molimm.2019.04.010 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1074/jbc.M114.582460 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.7554/eLife.14908 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.brainresrev.2003.11.004 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1093/hmg/ddq226 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1126/science.1161566 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.cmet.2011.01.010 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1159/000210400 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1093/brain/awu031 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1159/000504782 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/JNEUROSCI.3029-13.2013 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |1 Suzuki |y 2003 |2 Crossref |o Suzuki 2003 |
| 999 | C | 5 | |a 10.1016/S0166-2236(99)01500-3 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/s41419-021-03433-0 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1007/s12017-017-8450-1 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/bjp.2008.185 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1164/rccm.200507-1058OC |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1523/JNEUROSCI.3144-14.2015 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1152/ajpendo.00660.2011 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.18632/aging.103664 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/ncomms6416 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1038/sj.jcbfm.9600501 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1016/j.stemcr.2017.05.006 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1111/jcmm.15648 |9 -- missing cx lookup -- |2 Crossref |
| 999 | C | 5 | |a 10.1080/1061186X.2021.1882470 |9 -- missing cx lookup -- |1 Zhou |p 703 - |2 Crossref |t J Drug Target |v 29 |y 2021 |
| 999 | C | 5 | |a 10.1016/j.pneurobio.2018.12.001 |9 -- missing cx lookup -- |2 Crossref |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|