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| Home > Publications Database > The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses. > print |
| 001 | 163742 | ||
| 005 | 20230915090534.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pbio.3001503 |2 doi |
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| 037 | _ | _ | |a DZNE-2022-00481 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Schmerl, Bettina |b 0 |
| 245 | _ | _ | |a The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses. |
| 260 | _ | _ | |a Lawrence, KS |c 2022 |b PLoS |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Recent advances in imaging technology have highlighted that scaffold proteins and receptors are arranged in subsynaptic nanodomains. The synaptic membrane-associated guanylate kinase (MAGUK) scaffold protein membrane protein palmitoylated 2 (MPP2) is a component of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-associated protein complexes and also binds to the synaptic cell adhesion molecule SynCAM 1. Using superresolution imaging, we show that-like SynCAM 1-MPP2 is situated at the periphery of the postsynaptic density (PSD). In order to explore MPP2-associated protein complexes, we used a quantitative comparative proteomics approach and identified multiple γ-aminobutyric acid (GABA)A receptor subunits among novel synaptic MPP2 interactors. In line with a scaffold function for MPP2 in the assembly and/or modulation of intact GABAA receptors, manipulating MPP2 expression had effects on inhibitory synaptic transmission. We further show that GABAA receptors are found together with MPP2 in a subset of dendritic spines and thus highlight MPP2 as a scaffold that serves as an adaptor molecule, linking peripheral synaptic elements critical for inhibitory regulation to central structures at the PSD of glutamatergic synapses. |
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| 650 | _ | 7 | |a Membrane Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, AMPA |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, GABA-A |2 NLM Chemicals |
| 650 | _ | 2 | |a Membrane Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Post-Synaptic Density: metabolism |2 MeSH |
| 650 | _ | 2 | |a Receptors, AMPA: metabolism |2 MeSH |
| 650 | _ | 2 | |a Receptors, GABA-A |2 MeSH |
| 650 | _ | 2 | |a Synapses: metabolism |2 MeSH |
| 700 | 1 | _ | |a Gimber, Niclas |b 1 |
| 700 | 1 | _ | |a Kuropka, Benno |b 2 |
| 700 | 1 | _ | |a Stumpf, Alexander |b 3 |
| 700 | 1 | _ | |a Rentsch, Jakob |b 4 |
| 700 | 1 | _ | |a Kunde, Stella-Amrei |b 5 |
| 700 | 1 | _ | |a von Sivers, Judith |b 6 |
| 700 | 1 | _ | |a Ewers, Helge |b 7 |
| 700 | 1 | _ | |a Schmitz, Dietmar |0 P:(DE-2719)2810725 |b 8 |u dzne |
| 700 | 1 | _ | |a Freund, Christian |b 9 |
| 700 | 1 | _ | |a Schmoranzer, Jan |b 10 |
| 700 | 1 | _ | |a Rademacher, Nils |0 P:(DE-2719)2814334 |b 11 |u dzne |
| 700 | 1 | _ | |a Shoichet, Sarah A |0 0000-0003-4933-7846 |b 12 |
| 773 | _ | _ | |a 10.1371/journal.pbio.3001503 |g Vol. 20, no. 3, p. e3001503 - |0 PERI:(DE-600)2126773-X |n 3 |p e3001503 |t PLoS biology |v 20 |y 2022 |x 1544-9173 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/163742/files/DZNE-2022-00481.pdf |
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