%0 Journal Article
%A Zhang, Jin
%A Li, Zhenghui
%A Chandrasekar, Akila
%A Li, Shun
%A Ludolph, Albert
%A Böckers, Tobias
%A Huber-Lang, Markus
%A Roselli, Francesco
%A Olde Heuvel, Florian
%T Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.
%J Frontiers in immunology
%V 13
%@ 1664-3224
%C Lausanne
%I Frontiers Media
%M DZNE-2022-00484
%P 824459
%D 2022
%X The consequences of systemic inflammation are a significant burden after traumatic brain injury (TBI), with almost all organs affected. This response consists of inflammation and concurrent immunosuppression after injury. One of the main immune regulatory organs, the spleen, is highly interactive with the brain. Along this brain-spleen axis, both nerve fibers as well as brain-derived circulating mediators have been shown to interact directly with splenic immune cells. One of the most significant comorbidities in TBI is acute ethanol intoxication (EI), with almost 40
%K Brain Injuries, Traumatic: metabolism
%K Dendritic Cells
%K Humans
%K Inflammation
%K Membrane Proteins: genetics
%K Spleen
%K fms-Like Tyrosine Kinase 3
%K FLT3 (Other)
%K dendritic cell (Other)
%K ethanol (Other)
%K spleen (Other)
%K traumatic brain injury (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35281004
%2 pmc:PMC8907149
%R 10.3389/fimmu.2022.824459
%U https://pub.dzne.de/record/163745