000163745 001__ 163745
000163745 005__ 20240227115127.0
000163745 0247_ $$2doi$$a10.3389/fimmu.2022.824459
000163745 0247_ $$2pmid$$apmid:35281004
000163745 0247_ $$2pmc$$apmc:PMC8907149
000163745 0247_ $$2altmetric$$aaltmetric:123582560
000163745 037__ $$aDZNE-2022-00484
000163745 041__ $$aEnglish
000163745 082__ $$a610
000163745 1001_ $$aZhang, Jin$$b0
000163745 245__ $$aFast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.
000163745 260__ $$aLausanne$$bFrontiers Media$$c2022
000163745 3367_ $$2DRIVER$$aarticle
000163745 3367_ $$2DataCite$$aOutput Types/Journal article
000163745 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1709024784_12962
000163745 3367_ $$2BibTeX$$aARTICLE
000163745 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000163745 3367_ $$00$$2EndNote$$aJournal Article
000163745 520__ $$aThe consequences of systemic inflammation are a significant burden after traumatic brain injury (TBI), with almost all organs affected. This response consists of inflammation and concurrent immunosuppression after injury. One of the main immune regulatory organs, the spleen, is highly interactive with the brain. Along this brain-spleen axis, both nerve fibers as well as brain-derived circulating mediators have been shown to interact directly with splenic immune cells. One of the most significant comorbidities in TBI is acute ethanol intoxication (EI), with almost 40% of patients showing a positive blood alcohol level (BAL) upon injury. EI by itself has been shown to reduce proinflammatory mediators dose-dependently and enhance anti-inflammatory mediators in the spleen. However, how the splenic immune modulatory effect reacts to EI in TBI remains unclear. Therefore, we investigated early splenic immune responses after TBI with and without EI, using gene expression screening of cytokines and chemokines and fluorescence staining of thin spleen sections to investigate cellular mechanisms in immune cells. We found a strong FLT3/FLT3L induction 3 h after TBI, which was enhanced by EI. The FLT3L induction resulted in phosphorylation of FLT3 in CD11c+ dendritic cells, which enhanced protein synthesis, maturation process, and the immunity of dendritic cells, shown by pS6, peIF2A, MHC-II, LAMP1, and CD68 by immunostaining and TNF-α expression by in-situ hybridization. In conclusion, these data indicate that TBI induces a fast maturation and immunity of dendritic cells which is associated with FLT3/FLT3L signaling and which is enhanced by EI prior to TBI.
000163745 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000163745 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x1
000163745 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000163745 650_7 $$2Other$$aFLT3
000163745 650_7 $$2Other$$adendritic cell
000163745 650_7 $$2Other$$aethanol
000163745 650_7 $$2Other$$aspleen
000163745 650_7 $$2Other$$atraumatic brain injury
000163745 650_2 $$2MeSH$$aBrain Injuries, Traumatic: metabolism
000163745 650_2 $$2MeSH$$aDendritic Cells
000163745 650_2 $$2MeSH$$aHumans
000163745 650_2 $$2MeSH$$aInflammation
000163745 650_2 $$2MeSH$$aMembrane Proteins: genetics
000163745 650_2 $$2MeSH$$aSpleen
000163745 650_2 $$2MeSH$$afms-Like Tyrosine Kinase 3
000163745 7001_ $$aLi, Zhenghui$$b1
000163745 7001_ $$aChandrasekar, Akila$$b2
000163745 7001_ $$aLi, Shun$$b3
000163745 7001_ $$0P:(DE-2719)2812633$$aLudolph, Albert$$b4$$udzne
000163745 7001_ $$0P:(DE-2719)2812855$$aBöckers, Tobias$$b5$$udzne
000163745 7001_ $$aHuber-Lang, Markus$$b6
000163745 7001_ $$0P:(DE-2719)2812851$$aRoselli, Francesco$$b7$$udzne
000163745 7001_ $$aOlde Heuvel, Florian$$b8
000163745 773__ $$0PERI:(DE-600)2606827-8$$a10.3389/fimmu.2022.824459$$gVol. 13, p. 824459$$p824459$$tFrontiers in immunology$$v13$$x1664-3224$$y2022
000163745 8564_ $$uhttps://pub.dzne.de/record/163745/files/DZNE-2022-00484.pdf$$yOpenAccess
000163745 8564_ $$uhttps://pub.dzne.de/record/163745/files/DZNE-2022-00484.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000163745 909CO $$ooai:pub.dzne.de:163745$$pVDB$$popen_access$$popenaire$$pdnbdelivery$$pdriver
000163745 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812633$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000163745 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812855$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000163745 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812851$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000163745 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000163745 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x1
000163745 9141_ $$y2022
000163745 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-01-29
000163745 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-29
000163745 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-29
000163745 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-01-29
000163745 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000163745 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-01-29
000163745 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT IMMUNOL : 2021$$d2022-11-23
000163745 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-23
000163745 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-23
000163745 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-05-11T10:28:02Z
000163745 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-05-11T10:28:02Z
000163745 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-05-11T10:28:02Z
000163745 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-23
000163745 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-23
000163745 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bFRONT IMMUNOL : 2021$$d2022-11-23
000163745 9201_ $$0I:(DE-2719)5000077$$kClinical Study Center Ulm$$lClinical Study Center Ulm$$x0
000163745 9201_ $$0I:(DE-2719)1910002$$kAG Böckers$$lTranslational Protein Biochemistry$$x1
000163745 9201_ $$0I:(DE-2719)1910001$$kAG Roselli$$lMetabolic Changes in Neurodegeneration$$x2
000163745 980__ $$ajournal
000163745 980__ $$aVDB
000163745 980__ $$aI:(DE-2719)5000077
000163745 980__ $$aI:(DE-2719)1910002
000163745 980__ $$aI:(DE-2719)1910001
000163745 980__ $$aUNRESTRICTED
000163745 9801_ $$aFullTexts