TY  - JOUR
AU  - Zhang, Jin
AU  - Li, Zhenghui
AU  - Chandrasekar, Akila
AU  - Li, Shun
AU  - Ludolph, Albert
AU  - Böckers, Tobias
AU  - Huber-Lang, Markus
AU  - Roselli, Francesco
AU  - Olde Heuvel, Florian
TI  - Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.
JO  - Frontiers in immunology
VL  - 13
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2022-00484
SP  - 824459
PY  - 2022
AB  - The consequences of systemic inflammation are a significant burden after traumatic brain injury (TBI), with almost all organs affected. This response consists of inflammation and concurrent immunosuppression after injury. One of the main immune regulatory organs, the spleen, is highly interactive with the brain. Along this brain-spleen axis, both nerve fibers as well as brain-derived circulating mediators have been shown to interact directly with splenic immune cells. One of the most significant comorbidities in TBI is acute ethanol intoxication (EI), with almost 40
KW  - Brain Injuries, Traumatic: metabolism
KW  - Dendritic Cells
KW  - Humans
KW  - Inflammation
KW  - Membrane Proteins: genetics
KW  - Spleen
KW  - fms-Like Tyrosine Kinase 3
KW  - FLT3 (Other)
KW  - dendritic cell (Other)
KW  - ethanol (Other)
KW  - spleen (Other)
KW  - traumatic brain injury (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35281004
C2  - pmc:PMC8907149
DO  - DOI:10.3389/fimmu.2022.824459
UR  - https://pub.dzne.de/record/163745
ER  -