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000163756 041__ $$aEnglish
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000163756 1001_ $$0P:(DE-2719)9000492$$aBoccardi, Marina$$b0$$eFirst author$$udzne
000163756 245__ $$aClinical research in dementia: A perspective on implementing innovation.
000163756 260__ $$aHoboken, NJ$$bWiley$$c2022
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000163756 520__ $$aThe increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The first step in this direction requires outlining hurdles in the transition from research to practice. The different parties needed to support translational processes have communication mismatches; methodological gaps hamper evidence-based decision-making; and data are insufficient to provide reliable estimates of long-term health benefits and costs in decisional models. Pilot projects are tackling some of these gaps, but appropriate methods often still need to be devised or adapted to the dementia field. A consistent implementation perspective along the whole translational continuum, explicitly defined and shared among the relevant stakeholders, should overcome the 'research-versus-adoption' dichotomy, and tackle the implementation cliff early on. Concrete next steps may consist of providing tools that support the effective participation of heterogeneous stakeholders and agreeing on a definition of clinical significance that facilitates the selection of proper outcome measures.
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000163756 650_7 $$2Other$$aAlzheimer's disease
000163756 650_7 $$2Other$$aclinical innovation
000163756 650_7 $$2Other$$adementia
000163756 650_7 $$2Other$$aimplementation
000163756 650_7 $$2Other$$amethodology
000163756 650_7 $$2Other$$aneurocognitive disorders
000163756 650_7 $$2Other$$atranslational research
000163756 650_2 $$2MeSH$$aHumans
000163756 650_2 $$2MeSH$$aCommunication
000163756 650_2 $$2MeSH$$aPilot Projects
000163756 650_2 $$2MeSH$$aOutcome Assessment, Health Care
000163756 650_2 $$2MeSH$$aDementia: therapy
000163756 7001_ $$aHandels, Ron$$b1
000163756 7001_ $$aGold, Michael$$b2
000163756 7001_ $$0P:(DE-2719)9001307$$aGrazia, Alice$$b3$$udzne
000163756 7001_ $$aLutz, Michael W$$b4
000163756 7001_ $$aMartin, Mike$$b5
000163756 7001_ $$aNosheny, Rachel$$b6
000163756 7001_ $$aRobillard, Julie M$$b7
000163756 7001_ $$aWeidner, Wendy$$b8
000163756 7001_ $$aAlexandersson, Jan$$b9
000163756 7001_ $$0P:(DE-2719)2290613$$aThyrian, Jochen René$$b10$$udzne
000163756 7001_ $$aWinblad, Bengt$$b11
000163756 7001_ $$aBarbarino, Paola$$b12
000163756 7001_ $$aKhachaturian, Ara S$$b13
000163756 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b14$$eLast author$$udzne
000163756 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12622$$gp. alz.12622$$n11$$p2352-2367$$tAlzheimer's and dementia$$v18$$x1552-5260$$y2022
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