TY  - JOUR
AU  - Boccardi, Marina
AU  - Handels, Ron
AU  - Gold, Michael
AU  - Grazia, Alice
AU  - Lutz, Michael W
AU  - Martin, Mike
AU  - Nosheny, Rachel
AU  - Robillard, Julie M
AU  - Weidner, Wendy
AU  - Alexandersson, Jan
AU  - Thyrian, Jochen René
AU  - Winblad, Bengt
AU  - Barbarino, Paola
AU  - Khachaturian, Ara S
AU  - Teipel, Stefan
TI  - Clinical research in dementia: A perspective on implementing innovation.
JO  - Alzheimer's and dementia
VL  - 18
IS  - 11
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2022-00495
SP  - 2352-2367
PY  - 2022
N1  - (CC BY)
AB  - The increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The first step in this direction requires outlining hurdles in the transition from research to practice. The different parties needed to support translational processes have communication mismatches; methodological gaps hamper evidence-based decision-making; and data are insufficient to provide reliable estimates of long-term health benefits and costs in decisional models. Pilot projects are tackling some of these gaps, but appropriate methods often still need to be devised or adapted to the dementia field. A consistent implementation perspective along the whole translational continuum, explicitly defined and shared among the relevant stakeholders, should overcome the 'research-versus-adoption' dichotomy, and tackle the implementation cliff early on. Concrete next steps may consist of providing tools that support the effective participation of heterogeneous stakeholders and agreeing on a definition of clinical significance that facilitates the selection of proper outcome measures.
KW  - Humans
KW  - Communication
KW  - Pilot Projects
KW  - Outcome Assessment, Health Care
KW  - Dementia: therapy
KW  - Alzheimer's disease (Other)
KW  - clinical innovation (Other)
KW  - dementia (Other)
KW  - implementation (Other)
KW  - methodology (Other)
KW  - neurocognitive disorders (Other)
KW  - translational research (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35325508
DO  - DOI:10.1002/alz.12622
UR  - https://pub.dzne.de/record/163756
ER  -