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@ARTICLE{Boccardi:163756,
      author       = {Boccardi, Marina and Handels, Ron and Gold, Michael and
                      Grazia, Alice and Lutz, Michael W and Martin, Mike and
                      Nosheny, Rachel and Robillard, Julie M and Weidner, Wendy
                      and Alexandersson, Jan and Thyrian, Jochen René and
                      Winblad, Bengt and Barbarino, Paola and Khachaturian, Ara S
                      and Teipel, Stefan},
      title        = {{C}linical research in dementia: {A} perspective on
                      implementing innovation.},
      journal      = {Alzheimer's and dementia},
      volume       = {18},
      number       = {11},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2022-00495},
      pages        = {2352-2367},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {The increasing global prevalence of dementia demands
                      concrete actions that are aimed strategically at optimizing
                      processes that drive clinical innovation. The first step in
                      this direction requires outlining hurdles in the transition
                      from research to practice. The different parties needed to
                      support translational processes have communication
                      mismatches; methodological gaps hamper evidence-based
                      decision-making; and data are insufficient to provide
                      reliable estimates of long-term health benefits and costs in
                      decisional models. Pilot projects are tackling some of these
                      gaps, but appropriate methods often still need to be devised
                      or adapted to the dementia field. A consistent
                      implementation perspective along the whole translational
                      continuum, explicitly defined and shared among the relevant
                      stakeholders, should overcome the 'research-versus-adoption'
                      dichotomy, and tackle the implementation cliff early on.
                      Concrete next steps may consist of providing tools that
                      support the effective participation of heterogeneous
                      stakeholders and agreeing on a definition of clinical
                      significance that facilitates the selection of proper
                      outcome measures.},
      keywords     = {Humans / Communication / Pilot Projects / Outcome
                      Assessment, Health Care / Dementia: therapy / Alzheimer's
                      disease (Other) / clinical innovation (Other) / dementia
                      (Other) / implementation (Other) / methodology (Other) /
                      neurocognitive disorders (Other) / translational research
                      (Other)},
      cin          = {AG Boccardi / AG Thyrian / AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000062 / I:(DE-2719)1510800 /
                      I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35325508},
      doi          = {10.1002/alz.12622},
      url          = {https://pub.dzne.de/record/163756},
}