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001     163756
005     20230915090535.0
024 7 _ |a 10.1002/alz.12622
|2 doi
024 7 _ |a pmid:35325508
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024 7 _ |a 1552-5260
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024 7 _ |a 1552-5279
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037 _ _ |a DZNE-2022-00495
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Boccardi, Marina
|0 P:(DE-2719)9000492
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245 _ _ |a Clinical research in dementia: A perspective on implementing innovation.
260 _ _ |a Hoboken, NJ
|c 2022
|b Wiley
336 7 _ |a article
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336 7 _ |a Journal Article
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500 _ _ |a (CC BY)
520 _ _ |a The increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The first step in this direction requires outlining hurdles in the transition from research to practice. The different parties needed to support translational processes have communication mismatches; methodological gaps hamper evidence-based decision-making; and data are insufficient to provide reliable estimates of long-term health benefits and costs in decisional models. Pilot projects are tackling some of these gaps, but appropriate methods often still need to be devised or adapted to the dementia field. A consistent implementation perspective along the whole translational continuum, explicitly defined and shared among the relevant stakeholders, should overcome the 'research-versus-adoption' dichotomy, and tackle the implementation cliff early on. Concrete next steps may consist of providing tools that support the effective participation of heterogeneous stakeholders and agreeing on a definition of clinical significance that facilitates the selection of proper outcome measures.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a clinical innovation
|2 Other
650 _ 7 |a dementia
|2 Other
650 _ 7 |a implementation
|2 Other
650 _ 7 |a methodology
|2 Other
650 _ 7 |a neurocognitive disorders
|2 Other
650 _ 7 |a translational research
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Communication
|2 MeSH
650 _ 2 |a Pilot Projects
|2 MeSH
650 _ 2 |a Outcome Assessment, Health Care
|2 MeSH
650 _ 2 |a Dementia: therapy
|2 MeSH
700 1 _ |a Handels, Ron
|b 1
700 1 _ |a Gold, Michael
|b 2
700 1 _ |a Grazia, Alice
|0 P:(DE-2719)9001307
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700 1 _ |a Lutz, Michael W
|b 4
700 1 _ |a Martin, Mike
|b 5
700 1 _ |a Nosheny, Rachel
|b 6
700 1 _ |a Robillard, Julie M
|b 7
700 1 _ |a Weidner, Wendy
|b 8
700 1 _ |a Alexandersson, Jan
|b 9
700 1 _ |a Thyrian, Jochen René
|0 P:(DE-2719)2290613
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700 1 _ |a Winblad, Bengt
|b 11
700 1 _ |a Barbarino, Paola
|b 12
700 1 _ |a Khachaturian, Ara S
|b 13
700 1 _ |a Teipel, Stefan
|0 P:(DE-2719)2000026
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773 _ _ |a 10.1002/alz.12622
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856 4 _ |u https://pub.dzne.de/record/163756/files/DZNE-2022-00495.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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