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000163945 0247_ $$2doi$$a10.1016/j.celrep.2022.110746
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000163945 041__ $$aEnglish
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000163945 1001_ $$0P:(DE-2719)2811009$$aStürner, Tomke$$b0$$eFirst author
000163945 245__ $$aThe branching code: A model of actin-driven dendrite arborization.
000163945 260__ $$a[New York, NY]$$bElsevier$$c2022
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000163945 520__ $$aThe cytoskeleton is crucial for defining neuronal-type-specific dendrite morphologies. To explore how the complex interplay of actin-modulatory proteins (AMPs) can define neuronal types in vivo, we focused on the class III dendritic arborization (c3da) neuron of Drosophila larvae. Using computational modeling, we reveal that the main branches (MBs) of c3da neurons follow general models based on optimal wiring principles, while the actin-enriched short terminal branches (STBs) require an additional growth program. To clarify the cellular mechanisms that define this second step, we thus concentrated on STBs for an in-depth quantitative description of dendrite morphology and dynamics. Applying these methods systematically to mutants of six known and novel AMPs, we revealed the complementary roles of these individual AMPs in defining STB properties. Our data suggest that diverse dendrite arbors result from a combination of optimal-wiring-related growth and individualized growth programs that are neuron-type specific.
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000163945 650_7 $$2Other$$aCP: Molecular biology
000163945 650_7 $$2Other$$aCP: Neuroscience
000163945 650_7 $$2Other$$aDrosophila
000163945 650_7 $$2Other$$aactin
000163945 650_7 $$2Other$$aactin-modulatory proteins
000163945 650_7 $$2Other$$acomputational modeling
000163945 650_7 $$2Other$$adendrite
000163945 650_7 $$2Other$$adendritic arborization neurons
000163945 650_7 $$2Other$$amorphometrics
000163945 650_7 $$2Other$$aneuron
000163945 650_7 $$2Other$$aoptimal wiring
000163945 650_7 $$2Other$$atime-lapse imaging
000163945 650_7 $$2NLM Chemicals$$aActins
000163945 650_7 $$2NLM Chemicals$$aDrosophila Proteins
000163945 650_2 $$2MeSH$$aActins: metabolism
000163945 650_2 $$2MeSH$$aAnimals
000163945 650_2 $$2MeSH$$aDendrites: metabolism
000163945 650_2 $$2MeSH$$aDrosophila: metabolism
000163945 650_2 $$2MeSH$$aDrosophila Proteins: metabolism
000163945 650_2 $$2MeSH$$aNeuronal Plasticity
000163945 7001_ $$0P:(DE-2719)9001459$$aFerreira Castro, André$$b1
000163945 7001_ $$0P:(DE-2719)9002196$$aPhilipps, Maren$$b2$$udzne
000163945 7001_ $$aCuntz, Hermann$$b3
000163945 7001_ $$0P:(DE-2719)2810271$$aTavosanis, Gaia$$b4$$eLast author
000163945 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2022.110746$$gVol. 39, no. 4, p. 110746 -$$n4$$p110746$$tCell reports$$v39$$x2211-1247$$y2022
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