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@ARTICLE{Strner:163945,
      author       = {Stürner, Tomke and Ferreira Castro, André and Philipps,
                      Maren and Cuntz, Hermann and Tavosanis, Gaia},
      title        = {{T}he branching code: {A} model of actin-driven dendrite
                      arborization.},
      journal      = {Cell reports},
      volume       = {39},
      number       = {4},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2022-00619},
      pages        = {110746},
      year         = {2022},
      abstract     = {The cytoskeleton is crucial for defining
                      neuronal-type-specific dendrite morphologies. To explore how
                      the complex interplay of actin-modulatory proteins (AMPs)
                      can define neuronal types in vivo, we focused on the class
                      III dendritic arborization (c3da) neuron of Drosophila
                      larvae. Using computational modeling, we reveal that the
                      main branches (MBs) of c3da neurons follow general models
                      based on optimal wiring principles, while the actin-enriched
                      short terminal branches (STBs) require an additional growth
                      program. To clarify the cellular mechanisms that define this
                      second step, we thus concentrated on STBs for an in-depth
                      quantitative description of dendrite morphology and
                      dynamics. Applying these methods systematically to mutants
                      of six known and novel AMPs, we revealed the complementary
                      roles of these individual AMPs in defining STB properties.
                      Our data suggest that diverse dendrite arbors result from a
                      combination of optimal-wiring-related growth and
                      individualized growth programs that are neuron-type
                      specific.},
      keywords     = {Actins: metabolism / Animals / Dendrites: metabolism /
                      Drosophila: metabolism / Drosophila Proteins: metabolism /
                      Neuronal Plasticity / CP: Molecular biology (Other) / CP:
                      Neuroscience (Other) / Drosophila (Other) / actin (Other) /
                      actin-modulatory proteins (Other) / computational modeling
                      (Other) / dendrite (Other) / dendritic arborization neurons
                      (Other) / morphometrics (Other) / neuron (Other) / optimal
                      wiring (Other) / time-lapse imaging (Other) / Actins (NLM
                      Chemicals) / Drosophila Proteins (NLM Chemicals)},
      cin          = {AG Tavosanis / LAT},
      ddc          = {610},
      cid          = {I:(DE-2719)1013018 / I:(DE-2719)1040190},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35476974},
      doi          = {10.1016/j.celrep.2022.110746},
      url          = {https://pub.dzne.de/record/163945},
}