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001     163945
005     20230915090538.0
024 7 _ |a 10.1016/j.celrep.2022.110746
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100 1 _ |a Stürner, Tomke
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245 _ _ |a The branching code: A model of actin-driven dendrite arborization.
260 _ _ |a [New York, NY]
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520 _ _ |a The cytoskeleton is crucial for defining neuronal-type-specific dendrite morphologies. To explore how the complex interplay of actin-modulatory proteins (AMPs) can define neuronal types in vivo, we focused on the class III dendritic arborization (c3da) neuron of Drosophila larvae. Using computational modeling, we reveal that the main branches (MBs) of c3da neurons follow general models based on optimal wiring principles, while the actin-enriched short terminal branches (STBs) require an additional growth program. To clarify the cellular mechanisms that define this second step, we thus concentrated on STBs for an in-depth quantitative description of dendrite morphology and dynamics. Applying these methods systematically to mutants of six known and novel AMPs, we revealed the complementary roles of these individual AMPs in defining STB properties. Our data suggest that diverse dendrite arbors result from a combination of optimal-wiring-related growth and individualized growth programs that are neuron-type specific.
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650 _ 7 |a CP: Molecular biology
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650 _ 7 |a CP: Neuroscience
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650 _ 7 |a Drosophila
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650 _ 7 |a actin
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650 _ 7 |a actin-modulatory proteins
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650 _ 7 |a computational modeling
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650 _ 7 |a dendrite
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650 _ 7 |a dendritic arborization neurons
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650 _ 7 |a morphometrics
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650 _ 7 |a neuron
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650 _ 7 |a optimal wiring
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650 _ 7 |a time-lapse imaging
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650 _ 7 |a Actins
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650 _ 7 |a Drosophila Proteins
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650 _ 2 |a Actins: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Dendrites: metabolism
|2 MeSH
650 _ 2 |a Drosophila: metabolism
|2 MeSH
650 _ 2 |a Drosophila Proteins: metabolism
|2 MeSH
650 _ 2 |a Neuronal Plasticity
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700 1 _ |a Ferreira Castro, André
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700 1 _ |a Philipps, Maren
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700 1 _ |a Cuntz, Hermann
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700 1 _ |a Tavosanis, Gaia
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773 _ _ |a 10.1016/j.celrep.2022.110746
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856 4 _ |u https://pub.dzne.de/record/163945/files/DZNE-2022-00619.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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