TY  - JOUR
AU  - Wenning, Gregor K
AU  - Stankovic, Iva
AU  - Vignatelli, Luca
AU  - Fanciulli, Alessandra
AU  - Calandra-Buonaura, Giovanna
AU  - Seppi, Klaus
AU  - Palma, Jose-Alberto
AU  - Meissner, Wassilios G
AU  - Krismer, Florian
AU  - Berg, Daniela
AU  - Cortelli, Pietro
AU  - Freeman, Roy
AU  - Halliday, Glenda
AU  - Höglinger, Günter
AU  - Lang, Anthony
AU  - Ling, Helen
AU  - Litvan, Irene
AU  - Low, Phillip
AU  - Miki, Yasuo
AU  - Panicker, Jalesh
AU  - Pellecchia, Maria Teresa
AU  - Quinn, Niall
AU  - Sakakibara, Ryuji
AU  - Stamelou, Maria
AU  - Tolosa, Eduardo
AU  - Tsuji, Shoji
AU  - Warner, Tom
AU  - Poewe, Werner
AU  - Kaufmann, Horacio
TI  - The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.
JO  - Movement disorders
VL  - 37
IS  - 6
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2022-00626
SP  - 1131-1148
PY  - 2022
N1  - (CC BY)
AB  - The second consensus criteria for the diagnosis of multiple system atrophy (MSA) are widely recognized as the reference standard for clinical research, but lack sensitivity to diagnose the disease at early stages.To develop novel Movement Disorder Society (MDS) criteria for MSA diagnosis using an evidence-based and consensus-based methodology.We identified shortcomings of the second consensus criteria for MSA diagnosis and conducted a systematic literature review to answer predefined questions on clinical presentation and diagnostic tools relevant for MSA diagnosis. The criteria were developed and later optimized using two Delphi rounds within the MSA Criteria Revision Task Force, a survey for MDS membership, and a virtual Consensus Conference.The criteria for neuropathologically established MSA remain unchanged. For a clinical MSA diagnosis a new category of clinically established MSA is introduced, aiming for maximum specificity with acceptable sensitivity. A category of clinically probable MSA is defined to enhance sensitivity while maintaining specificity. A research category of possible prodromal MSA is designed to capture patients in the earliest stages when symptoms and signs are present, but do not meet the threshold for clinically established or clinically probable MSA. Brain magnetic resonance imaging markers suggestive of MSA are required for the diagnosis of clinically established MSA. The number of research biomarkers that support all clinical diagnostic categories will likely grow.This set of MDS MSA diagnostic criteria aims at improving the diagnostic accuracy, particularly in early disease stages. It requires validation in a prospective clinical and a clinicopathological study. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
KW  - Brain: pathology
KW  - Consensus
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Multiple System Atrophy: diagnosis
KW  - Multiple System Atrophy: pathology
KW  - Prospective Studies
KW  - diagnosis (Other)
KW  - diagnostic criteria (Other)
KW  - multiple system atrophy (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9321158
C6  - pmid:35445419
DO  - DOI:10.1002/mds.29005
UR  - https://pub.dzne.de/record/163952
ER  -