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000163975 1001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b0$$eFirst author
000163975 245__ $$aSubjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers.
000163975 260__ $$aHoboken, NJ$$bWiley$$c2023
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000163975 520__ $$aIt is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of the initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum.Cross-sectional and longitudinal data from the multicenter, memory clinic-based DELCODE study.The SCD group showed slightly worse cognition as well as more subtle functional and behavioral symptoms than the control group (CO). SCD-A+ cases (39.3% of all SCD) showed greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms than CO-A+. Amyloid concentration in the CSF had a greater effect on longitudinal cognitive decline in SCD than in the CO group.Our data suggests that SCD serves the identification of stage 2 of the AD continuum and that stage 2, operationalized as SCD-A+, is associated with subtle, but extended impact of AD pathology in terms of neurodegeneration, symptoms and clinical progression.
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000163975 650_7 $$2Other$$aAlzheimer's disease
000163975 650_7 $$2Other$$aamyloid beta 42
000163975 650_7 $$2Other$$aapolipoprotein E
000163975 650_7 $$2Other$$acerebrospinal fluid
000163975 650_7 $$2Other$$alongitudinal
000163975 650_7 $$2Other$$amagnetic resonance imaging
000163975 650_7 $$2Other$$amild cognitive impairment
000163975 650_7 $$2Other$$apositron emission tomography
000163975 650_7 $$2Other$$asubjective cognitive decline
000163975 650_7 $$2Other$$atau
000163975 650_2 $$2MeSH$$aHumans
000163975 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000163975 650_2 $$2MeSH$$aAmyloid beta-Peptides
000163975 650_2 $$2MeSH$$aCross-Sectional Studies
000163975 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000163975 650_2 $$2MeSH$$aCognition
000163975 650_2 $$2MeSH$$aBiomarkers
000163975 650_2 $$2MeSH$$atau Proteins
000163975 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000163975 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b1
000163975 7001_ $$0P:(DE-HGF)0$$aKleineindam, Luca$$b2
000163975 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b3
000163975 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b4
000163975 7001_ $$0P:(DE-2719)9000444$$aBartels, Claudia$$b5
000163975 7001_ $$aBerger, Moritz$$b6
000163975 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b7
000163975 7001_ $$0P:(DE-2719)2811028$$aDaamen, Marcel$$b8
000163975 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b9
000163975 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b10
000163975 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b11
000163975 7001_ $$aFenski, Friederike$$b12
000163975 7001_ $$0P:(DE-2719)2811326$$aFließbach, Klaus$$b13
000163975 7001_ $$0P:(DE-2719)2812392$$aFreiesleben, Silka Dawn$$b14
000163975 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b15
000163975 7001_ $$0P:(DE-2719)2812583$$aGörß, Doreen$$b16
000163975 7001_ $$aGürsel, Selim$$b17
000163975 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b18$$udzne
000163975 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b19
000163975 7001_ $$0P:(DE-2719)9001475$$aKobeleva, Xenia$$b20
000163975 7001_ $$0P:(DE-2719)2811189$$aLohse, Andrea$$b21
000163975 7001_ $$aMaier, Franziska$$b22
000163975 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline$$b23
000163975 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias$$b24
000163975 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b25
000163975 7001_ $$0P:(DE-2719)2812865$$aSanzenbacher, Carolin$$b26
000163975 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b27
000163975 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b28
000163975 7001_ $$0P:(DE-2719)9001493$$aVukovich, Ruth C.$$b29
000163975 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b30
000163975 7001_ $$0P:(DE-2719)9002221$$aWeyrauch, Anne-Sophie$$b31$$udzne
000163975 7001_ $$0P:(DE-2719)2814076$$aZiegler, Gabriel$$b32
000163975 7001_ $$0P:(DE-2719)2811245$$aSchmid, Matthias$$b33
000163975 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b34
000163975 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b35
000163975 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b36
000163975 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b37
000163975 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b38
000163975 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b39
000163975 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b40
000163975 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b41
000163975 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b42
000163975 7001_ $$0P:(DE-2719)2810726$$aBoecker, Henning$$b43
000163975 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b44
000163975 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b45
000163975 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b46$$eLast author
000163975 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12674$$gp. alz.12674$$n2$$p487-497$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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