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@ARTICLE{Jessen:163975,
      author       = {Jessen, Frank and Wolfsgruber, Steffen and Kleineindam,
                      Luca and Spottke, Annika and Altenstein, Slawek and Bartels,
                      Claudia and Berger, Moritz and Brosseron, Frederic and
                      Daamen, Marcel and Dichgans, Martin and Dobisch, Laura and
                      Ewers, Michael and Fenski, Friederike and Fließbach, Klaus
                      and Freiesleben, Silka Dawn and Glanz, Wenzel and Görß,
                      Doreen and Gürsel, Selim and Janowitz, Daniel and Kilimann,
                      Ingo and Kobeleva, Xenia and Lohse, Andrea and Maier,
                      Franziska and Metzger, Coraline and Munk, Matthias and
                      Preis, Lukas and Sanzenbacher, Carolin and Spruth, Eike
                      Jakob and Rauchmann, Boris Stephan and Vukovich, Ruth C. and
                      Yakupov, Renat and Weyrauch, Anne-Sophie and Ziegler,
                      Gabriel and Schmid, Matthias and Laske, Christoph and
                      Perneczky, Robert and Schneider, Anja and Wiltfang, Jens and
                      Teipel, Stefan and Bürger, Katharina and Priller, Josef and
                      Peters, Oliver and Ramirez, Alfredo and Boecker, Henning and
                      Heneka, Michael T and Wagner, Michael and Düzel, Emrah},
      title        = {{S}ubjective cognitive decline and stage 2 of {A}lzheimer
                      disease in patients from memory centers.},
      journal      = {Alzheimer's and dementia},
      volume       = {19},
      number       = {2},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2022-00644},
      pages        = {487-497},
      year         = {2023},
      note         = {(CC BY-NC-ND)},
      abstract     = {It is uncertain whether subjective cognitive decline (SCD)
                      in individuals who seek medical help serves the
                      identification of the initial symptomatic stage 2 of the
                      Alzheimer's disease (AD) continuum.Cross-sectional and
                      longitudinal data from the multicenter, memory clinic-based
                      DELCODE study.The SCD group showed slightly worse cognition
                      as well as more subtle functional and behavioral symptoms
                      than the control group (CO). SCD-A+ cases $(39.3\%$ of all
                      SCD) showed greater hippocampal atrophy, lower cognitive and
                      functional performance, and more behavioral symptoms than
                      CO-A+. Amyloid concentration in the CSF had a greater effect
                      on longitudinal cognitive decline in SCD than in the CO
                      group.Our data suggests that SCD serves the identification
                      of stage 2 of the AD continuum and that stage 2,
                      operationalized as SCD-A+, is associated with subtle, but
                      extended impact of AD pathology in terms of
                      neurodegeneration, symptoms and clinical progression.},
      keywords     = {Humans / Alzheimer Disease: pathology / Amyloid
                      beta-Peptides / Cross-Sectional Studies / Cognitive
                      Dysfunction: diagnosis / Cognition / Biomarkers / tau
                      Proteins / Alzheimer's disease (Other) / amyloid beta 42
                      (Other) / apolipoprotein E (Other) / cerebrospinal fluid
                      (Other) / longitudinal (Other) / magnetic resonance imaging
                      (Other) / mild cognitive impairment (Other) / positron
                      emission tomography (Other) / subjective cognitive decline
                      (Other) / tau (Other)},
      cin          = {AG Jessen / AG Wagner / AG Klockgether / AG Endres /
                      Biomarker / AG Boecker / Clinical Research (Munich) / AG
                      Speck / KAP / AG Düzel / AG Teipel / AG Schmid Bonn / Core
                      ICRU / AG Schneider / AG Priller / Patient Studies Bonn /
                      Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)1011102 / I:(DE-2719)1011201 /
                      I:(DE-2719)1011001 / I:(DE-2719)1811005 / I:(DE-2719)1011301
                      / I:(DE-2719)1011202 / I:(DE-2719)1111015 /
                      I:(DE-2719)1340009 / I:(DE-2719)1340013 / I:(DE-2719)5000006
                      / I:(DE-2719)1510100 / I:(DE-2719)1013028 /
                      I:(DE-2719)1240005 / I:(DE-2719)1011305 / I:(DE-2719)5000007
                      / I:(DE-2719)1011101 / I:(DE-2719)5000034},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35451563},
      doi          = {10.1002/alz.12674},
      url          = {https://pub.dzne.de/record/163975},
}