Home > Publications Database > Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. > print

001     163975
005     20240826165946.0
024 7 _ |a 10.1002/alz.12674
|2 doi
024 7 _ |a pmid:35451563
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024 7 _ |a 1552-5260
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024 7 _ |a 1552-5279
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037 _ _ |a DZNE-2022-00644
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Jessen, Frank
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245 _ _ |a Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers.
260 _ _ |a Hoboken, NJ
|c 2023
|b Wiley
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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500 _ _ |a (CC BY-NC-ND)
520 _ _ |a It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of the initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum.Cross-sectional and longitudinal data from the multicenter, memory clinic-based DELCODE study.The SCD group showed slightly worse cognition as well as more subtle functional and behavioral symptoms than the control group (CO). SCD-A+ cases (39.3% of all SCD) showed greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms than CO-A+. Amyloid concentration in the CSF had a greater effect on longitudinal cognitive decline in SCD than in the CO group.Our data suggests that SCD serves the identification of stage 2 of the AD continuum and that stage 2, operationalized as SCD-A+, is associated with subtle, but extended impact of AD pathology in terms of neurodegeneration, symptoms and clinical progression.
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650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a amyloid beta 42
|2 Other
650 _ 7 |a apolipoprotein E
|2 Other
650 _ 7 |a cerebrospinal fluid
|2 Other
650 _ 7 |a longitudinal
|2 Other
650 _ 7 |a magnetic resonance imaging
|2 Other
650 _ 7 |a mild cognitive impairment
|2 Other
650 _ 7 |a positron emission tomography
|2 Other
650 _ 7 |a subjective cognitive decline
|2 Other
650 _ 7 |a tau
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: diagnosis
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Biomarkers
|2 MeSH
650 _ 2 |a tau Proteins
|2 MeSH
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700 1 _ |a Wolfsgruber, Steffen
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700 1 _ |a Kleineindam, Luca
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700 1 _ |a Dichgans, Martin
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700 1 _ |a Ewers, Michael
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700 1 _ |a Fenski, Friederike
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700 1 _ |a Fließbach, Klaus
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700 1 _ |a Freiesleben, Silka Dawn
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700 1 _ |a Glanz, Wenzel
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700 1 _ |a Görß, Doreen
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700 1 _ |a Gürsel, Selim
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700 1 _ |a Lohse, Andrea
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700 1 _ |a Maier, Franziska
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700 1 _ |a Metzger, Coraline
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700 1 _ |a Munk, Matthias
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700 1 _ |a Preis, Lukas
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700 1 _ |a Sanzenbacher, Carolin
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700 1 _ |a Spruth, Eike Jakob
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700 1 _ |a Rauchmann, Boris Stephan
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700 1 _ |a Vukovich, Ruth C.
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700 1 _ |a Yakupov, Renat
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700 1 _ |a Ziegler, Gabriel
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700 1 _ |a Schmid, Matthias
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700 1 _ |a Laske, Christoph
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700 1 _ |a Perneczky, Robert
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700 1 _ |a Schneider, Anja
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700 1 _ |a Wiltfang, Jens
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700 1 _ |a Teipel, Stefan
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700 1 _ |a Bürger, Katharina
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700 1 _ |a Priller, Josef
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700 1 _ |a Peters, Oliver
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700 1 _ |a Ramirez, Alfredo
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700 1 _ |a Boecker, Henning
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700 1 _ |a Heneka, Michael T
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700 1 _ |a Wagner, Michael
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700 1 _ |a Düzel, Emrah
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773 _ _ |a 10.1002/alz.12674
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