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| 001 | 163984 | ||
| 005 | 20240717143409.0 | ||
| 024 | 7 | _ | |a 10.3233/JPD-212787 |2 doi |
| 024 | 7 | _ | |a pmid:35068416 |2 pmid |
| 024 | 7 | _ | |a 1877-7171 |2 ISSN |
| 024 | 7 | _ | |a 1877-718X |2 ISSN |
| 024 | 7 | _ | |a altmetric:121514917 |2 altmetric |
| 037 | _ | _ | |a DZNE-2022-00653 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Michels, Jennifer |b 0 |
| 245 | _ | _ | |a Long-Term Cognitive Decline Related to the Motor Phenotype in Parkinson's Disease. |
| 260 | _ | _ | |a Amsterdam |c 2022 |b IOS Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1721219631_5185 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Parkinson's disease (PD) is associated with various non-motor symptoms, including cognitive deterioration.Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND).Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M = 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year follow-up data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M = 66.10; 68.6% males).Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients were present and we found differences for motor phenotypes in attention (β= -0.08, SE = 0.003, p < 0.006) and memory functions showing that PIGD-patients deteriorate per months by -0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living.Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Cognitive decline |2 Other |
| 650 | _ | 7 | |a Parkinson’s disease |2 Other |
| 650 | _ | 7 | |a dementia |2 Other |
| 650 | _ | 7 | |a longitudinal |2 Other |
| 650 | _ | 7 | |a mild cognitive impairment |2 Other |
| 650 | _ | 7 | |a postural instability and gait disorder |2 Other |
| 650 | _ | 7 | |a progression |2 Other |
| 650 | _ | 7 | |a tremor-dominant |2 Other |
| 650 | _ | 2 | |a Cognitive Dysfunction: complications |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Gait Disorders, Neurologic: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Neuropsychological Tests |2 MeSH |
| 650 | _ | 2 | |a Parkinson Disease: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Phenotype |2 MeSH |
| 650 | _ | 2 | |a Postural Balance |2 MeSH |
| 650 | _ | 2 | |a Tremor: diagnosis |2 MeSH |
| 700 | 1 | _ | |a van der Wurp, Hendrik |b 1 |
| 700 | 1 | _ | |a Kalbe, Elke |b 2 |
| 700 | 1 | _ | |a Rehberg, Sarah |b 3 |
| 700 | 1 | _ | |a Storch, Alexander |0 P:(DE-2719)9000306 |b 4 |
| 700 | 1 | _ | |a Linse, Katharina |0 P:(DE-2719)2812121 |b 5 |
| 700 | 1 | _ | |a Schneider, Christine |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Gräber, Susanne |0 P:(DE-2719)2810662 |b 7 |
| 700 | 1 | _ | |a Berg, Daniela |0 P:(DE-2719)2000059 |b 8 |
| 700 | 1 | _ | |a Dams, Judith |b 9 |
| 700 | 1 | _ | |a Balzer-Geldsetzer, Monika |b 10 |
| 700 | 1 | _ | |a Hilker-Roggendorf, Rüdiger |b 11 |
| 700 | 1 | _ | |a Oberschmidt, Carola |b 12 |
| 700 | 1 | _ | |a Baudrexel, Simon |b 13 |
| 700 | 1 | _ | |a Witt, Karsten |b 14 |
| 700 | 1 | _ | |a Schmidt, Nele |b 15 |
| 700 | 1 | _ | |a Deuschl, Günther |0 P:(DE-2719)9000934 |b 16 |
| 700 | 1 | _ | |a Mollenhauer, Brit |0 P:(DE-2719)9001340 |b 17 |
| 700 | 1 | _ | |a Trenkwalder, Claudia |b 18 |
| 700 | 1 | _ | |a Liepelt-Scarfone, Inga |0 P:(DE-2719)2109499 |b 19 |
| 700 | 1 | _ | |a Spottke, Annika |0 P:(DE-2719)2811324 |b 20 |
| 700 | 1 | _ | |a Roeske, Sandra |0 P:(DE-2719)2810395 |b 21 |
| 700 | 1 | _ | |a Wüllner, Ullrich |0 P:(DE-2719)2000056 |b 22 |
| 700 | 1 | _ | |a Wittchen, Hans-Ulrich |b 23 |
| 700 | 1 | _ | |a Riedel, Oliver |b 24 |
| 700 | 1 | _ | |a Kassubek, Jan |0 P:(DE-2719)9001967 |b 25 |
| 700 | 1 | _ | |a Dodel, Richard |0 P:(DE-2719)9000057 |b 26 |
| 700 | 1 | _ | |a Schulz, Jörg Bernhard |b 27 |
| 700 | 1 | _ | |a Costa, Ana Sofia |b 28 |
| 700 | 1 | _ | |a Reetz, Kathrin |b 29 |
| 773 | _ | _ | |a 10.3233/JPD-212787 |g Vol. 12, no. 3, p. 905 - 916 |0 PERI:(DE-600)2599550-9 |n 3 |p 905 - 916 |t Journal of Parkinson's Disease |v 12 |y 2022 |x 1877-7171 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/163984/files/DZNE-2022-00653_Restricted.pdf |
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| 914 | 1 | _ | |y 2022 |
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