%0 Journal Article
%A Liu, Chunxin
%A Lu, Yaxin
%A Chen, Jingjing
%A Qiu, Wei
%A Zhan, Yiqiang
%A Liu, Zifeng
%T Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study.
%J Metabolic brain disease
%V 37
%N 6
%@ 0885-7490
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M DZNE-2022-00693
%P 1855-1861
%D 2022
%X To determine the relationship between basal metabolic rate (BMR) and multiple sclerosis (MS) susceptibility, we analyzed genome-wide association study (GWAS) summary statistics data from the International Multiple Sclerosis Genetics Consortium on a total of 115,803 participants of European descent, including 47,429 patients with MS and 68,374 controls. We selected 378 independent genetic variants strongly associated with BMR in a GWAS involving 454,874 participants as instrumental variables to examine a potential causal relationship between BMR and MS. A genetically predicted higher BMR was associated with a greater risk of MS (odds ratio [OR]: 1.283 per one standard deviation increase in BMR, 95
%K Basal Metabolism: genetics
%K Genome-Wide Association Study
%K Humans
%K Mendelian Randomization Analysis
%K Multiple Sclerosis: epidemiology
%K Multiple Sclerosis: genetics
%K Polymorphism, Single Nucleotide: genetics
%K Basal metabolic rate (Other)
%K Genome-wide association study (Other)
%K Mendelian randomization (Other)
%K Multiple sclerosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35543713
%R 10.1007/s11011-022-00973-y
%U https://pub.dzne.de/record/164030