TY  - JOUR
AU  - Liu, Chunxin
AU  - Lu, Yaxin
AU  - Chen, Jingjing
AU  - Qiu, Wei
AU  - Zhan, Yiqiang
AU  - Liu, Zifeng
TI  - Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study.
JO  - Metabolic brain disease
VL  - 37
IS  - 6
SN  - 0885-7490
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DZNE-2022-00693
SP  - 1855-1861
PY  - 2022
AB  - To determine the relationship between basal metabolic rate (BMR) and multiple sclerosis (MS) susceptibility, we analyzed genome-wide association study (GWAS) summary statistics data from the International Multiple Sclerosis Genetics Consortium on a total of 115,803 participants of European descent, including 47,429 patients with MS and 68,374 controls. We selected 378 independent genetic variants strongly associated with BMR in a GWAS involving 454,874 participants as instrumental variables to examine a potential causal relationship between BMR and MS. A genetically predicted higher BMR was associated with a greater risk of MS (odds ratio [OR]: 1.283 per one standard deviation increase in BMR, 95
KW  - Basal Metabolism: genetics
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Mendelian Randomization Analysis
KW  - Multiple Sclerosis: epidemiology
KW  - Multiple Sclerosis: genetics
KW  - Polymorphism, Single Nucleotide: genetics
KW  - Basal metabolic rate (Other)
KW  - Genome-wide association study (Other)
KW  - Mendelian randomization (Other)
KW  - Multiple sclerosis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35543713
DO  - DOI:10.1007/s11011-022-00973-y
UR  - https://pub.dzne.de/record/164030
ER  -