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@ARTICLE{Liu:164030,
      author       = {Liu, Chunxin and Lu, Yaxin and Chen, Jingjing and Qiu, Wei
                      and Zhan, Yiqiang and Liu, Zifeng},
      title        = {{B}asal metabolic rate and risk of multiple sclerosis: a
                      {M}endelian randomization study.},
      journal      = {Metabolic brain disease},
      volume       = {37},
      number       = {6},
      issn         = {0885-7490},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DZNE-2022-00693},
      pages        = {1855-1861},
      year         = {2022},
      abstract     = {To determine the relationship between basal metabolic rate
                      (BMR) and multiple sclerosis (MS) susceptibility, we
                      analyzed genome-wide association study (GWAS) summary
                      statistics data from the International Multiple Sclerosis
                      Genetics Consortium on a total of 115,803 participants of
                      European descent, including 47,429 patients with MS and
                      68,374 controls. We selected 378 independent genetic
                      variants strongly associated with BMR in a GWAS involving
                      454,874 participants as instrumental variables to examine a
                      potential causal relationship between BMR and MS. A
                      genetically predicted higher BMR was associated with a
                      greater risk of MS (odds ratio [OR]: 1.283 per one standard
                      deviation increase in BMR, $95\%$ confidence interval [CI]:
                      1.108-1.486, P = 0.001). Moreover, we used the lasso method
                      to eliminate heterogeneity (Q statistic = 384.58, P =
                      0.370). There was no pleiotropy in our study and no bias was
                      found in the sensitivity analysis using the leave-one-out
                      test. We provide novel evidence that a higher BMR is an
                      independent causal risk factor in the development of MS.
                      Further work is warranted to elucidate the potential
                      mechanisms.},
      keywords     = {Basal Metabolism: genetics / Genome-Wide Association Study
                      / Humans / Mendelian Randomization Analysis / Multiple
                      Sclerosis: epidemiology / Multiple Sclerosis: genetics /
                      Polymorphism, Single Nucleotide: genetics / Basal metabolic
                      rate (Other) / Genome-wide association study (Other) /
                      Mendelian randomization (Other) / Multiple sclerosis
                      (Other)},
      cin          = {AG Zhan},
      ddc          = {610},
      cid          = {I:(DE-2719)1910005},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35543713},
      doi          = {10.1007/s11011-022-00973-y},
      url          = {https://pub.dzne.de/record/164030},
}